| Literature DB >> 25633593 |
Chuan Wu1, Zuojia Chen1, Vijay K Kuchroo1.
Abstract
The genomic and transcriptomic analysis has led to the identification of transcriptional networks that affect the differentiation of Th17 cells, while the protein-protein networks and the posttranslational modifications that control the development of Th17 cells have not been established yet. A recent publication by Rutz et al. in Nature describes a novel deubiquitylating enzyme DUBA as a negative regulator for IL-17 by regulating stability of RORγt, the master transcription factor that induces Th17 cells.Entities:
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Year: 2015 PMID： 25633593 PMCID： PMC4349248 DOI： 10.1038/cr.2015.13
Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617