Dag G Ellingsen1, Bente Ulvestad2,3, Berit Bakke2, Ingebjørg Seljeflot4,5, Lars Barregard6, Yngvar Thomassen2. 1. National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway. dag.ellingsen@stami.no. 2. National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway. 3. Department of Occupational Medicine, Mesta AS, Moss, Norway. 4. Department of Cardiology, Center for Clinical Heart Research, Oslo University Hospital Ullevål, Oslo, Norway. 5. Faculty of Medicine, University of Oslo, Oslo, Norway. 6. Department of Occupational and Environmental Medicine, University of Gothenburg, Göteborg, Sweden.
Abstract
PURPOSE: The aim was to study inflammatory biomarkers in tunnel construction workers (TCW). METHODS: Surfactant protein D (SP-D), Clara cell protein 16 (CC-16) and C-reactive protein (CRP) were studied in serum of 90 TCW and 50 referents before and at the end of an 11-day work period. Personal air sampling was carried out on the two consecutive days before follow-up. RESULTS: The TCW's geometric mean exposure to particulate matter and α-quartz were 604 and 74 µg/m(3), respectively. The arithmetic mean concentration of elemental carbon was 51 µg/m(3). The arithmetic mean concentration of SP-D was reduced by 7.6 µg/L in the TCWs and 0.6 µg/L in the referents (p = 0.04) at the end as compared to before the work period. Subjects who had ever been TCW had lower arithmetic mean CC-16 concentrations at baseline (5.4 µg/L) than subjects who had never worked as TCW (6.4 µg/L). Years worked as TCW was significantly associated with an annual mean decline of the CC-16 concentration of 0.04 µg/L. The concentrations of the biomarker of systemic inflammation, CRP, were not affected by exposure in the TCWs. Current smoking and body mass index have a large impact on the measured biomarker concentrations. CONCLUSIONS: The results suggest that former and current TCWs have lower serum CC-16 concentrations than referents, while the concentrations of SP-D decreased during exposure. The serum biomarker of systemic inflammation, CRP, was not altered during exposure. Current smoking and BMI were related to the concentrations of all measured biomarkers.
PURPOSE: The aim was to study inflammatory biomarkers in tunnel construction workers (TCW). METHODS:Surfactant protein D (SP-D), Clara cell protein 16 (CC-16) and C-reactive protein (CRP) were studied in serum of 90 TCW and 50 referents before and at the end of an 11-day work period. Personal air sampling was carried out on the two consecutive days before follow-up. RESULTS: The TCW's geometric mean exposure to particulate matter and α-quartz were 604 and 74 µg/m(3), respectively. The arithmetic mean concentration of elemental carbon was 51 µg/m(3). The arithmetic mean concentration of SP-D was reduced by 7.6 µg/L in the TCWs and 0.6 µg/L in the referents (p = 0.04) at the end as compared to before the work period. Subjects who had ever been TCW had lower arithmetic mean CC-16 concentrations at baseline (5.4 µg/L) than subjects who had never worked as TCW (6.4 µg/L). Years worked as TCW was significantly associated with an annual mean decline of the CC-16 concentration of 0.04 µg/L. The concentrations of the biomarker of systemic inflammation, CRP, were not affected by exposure in the TCWs. Current smoking and body mass index have a large impact on the measured biomarker concentrations. CONCLUSIONS: The results suggest that former and current TCWs have lower serum CC-16 concentrations than referents, while the concentrations of SP-D decreased during exposure. The serum biomarker of systemic inflammation, CRP, was not altered during exposure. Current smoking and BMI were related to the concentrations of all measured biomarkers.
Authors: Dag G Ellingsen; Ingebjørg Seljeflot; Yngvar Thomassen; Magny Thomassen; Berit Bakke; Bente Ulvestad Journal: Int Arch Occup Environ Health Date: 2017-01-25 Impact factor: 3.015
Authors: Lena Andersson; Ing-Liss Bryngelsson; Alexander Hedbrant; Alexander Persson; Anders Johansson; Annette Ericsson; Ina Lindell; Leo Stockfelt; Eva Särndahl; Håkan Westberg Journal: PLoS One Date: 2019-11-01 Impact factor: 3.240