Literature DB >> 2563253

Presymptomatic testing for Huntington's disease. A case complicated by recombination within the D4S10 locus.

A Curtis1, F Millan, S Holloway, M Mennie, A Crosbie, J A Raeburn, D J Brock.   

Abstract

Presymptomatic testing for Huntington's disease (HD) is possible through the use of restriction fragment length polymorphisms (RFLPs) at the closely linked D4S10 locus. Recombination between the HD and D4S10 loci will occur in 4%-5% of meioses, and is a well-recognised complication of predictive testing. Recombination between RFLPs within the D4S10 locus is a rare event and can usually be ignored. We report a case where such an intra-locus recombination frustrated attempts to predict the chance of a high-risk individual inheriting the HD gene.

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Year:  1989        PMID： 2563253     DOI： 10.1007/BF00293901

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

Review 1.  Huntington's disease. Pathogenesis and management.

Authors:  J B Martin; J F Gusella
Journal:  N Engl J Med       Date:  1986-11-13       Impact factor: 91.245

2.  A life table for onset of Huntington's chorea.

Authors:  R G Newcombe
Journal:  Ann Hum Genet       Date:  1981-10       Impact factor: 1.670

3.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

Review 4.  Huntington disease: genetics and epidemiology.

Authors:  P M Conneally
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

5.  Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.

Authors:  T C Gilliam; R E Tanzi; J L Haines; T I Bonner; A G Faryniarz; W J Hobbs; M E MacDonald; S V Cheng; S E Folstein; P M Conneally
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

6.  A DNA segment encoding two genes very tightly linked to Huntington's disease.

Authors:  T C Gilliam; M Bucan; M E MacDonald; M Zimmer; J L Haines; S V Cheng; T M Pohl; R H Meyers; W L Whaley; B A Allitto
Journal:  Science       Date:  1987-11-13       Impact factor: 47.728

7.  Predictive testing for Huntington's disease with use of a linked DNA marker.

Authors:  G J Meissen; R H Myers; C A Mastromauro; W J Koroshetz; K W Klinger; L A Farrer; P A Watkins; J F Gusella; E D Bird; J B Martin
Journal:  N Engl J Med       Date:  1988-03-03       Impact factor: 91.245

8.  Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.

Authors:  J F Gusella; R E Tanzi; P I Bader; M C Phelan; R Stevenson; M R Hayden; K J Hofman; A G Faryniarz; K Gibbons
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962

9.  Attitudes of persons at risk for Huntington disease toward predictive testing.

Authors:  S Kessler; T Field; L Worth; H Mosbarger
Journal:  Am J Med Genet       Date:  1987-02

Review 10.  The prevention of Huntington's chorea. The Milroy lecture 1985.

Authors:  P S Harper
Journal:  J R Coll Physicians Lond       Date:  1986-01
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  2 in total

1.  Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Authors:  I Kanazawa; I Kondo; J E Ikeda; T Ikeda; Y Shizu; M Yoshida; H Narabayashi; S Kuroda; H Tsunoda; E Mizuta
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

2.  The paradigm of Huntington disease.

Authors:  J B Jenkins; P M Conneally
Journal:  Am J Hum Genet       Date:  1989-07       Impact factor: 11.025
  2 in total

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