BACKGROUND: Tall people have an increased risk of a first venous thrombosis. Sedentary lifestyle has been shown to act synergistically with body height, especially during long-haul flights. OBJECTIVE: To estimate the relation between height and risk of a first and recurrent venous thrombosis and a possible additional association with a mobile or an immobile lifestyle. METHODS: Patients with a first venous thrombosis and control subjects were included between 1999 and 2004 (MEGA case-control study). Patients were followed for recurrence for an average time of 5.1 years (MEGA follow-up study). Odds ratios and hazard ratios (HRs) per increase of 5 cm were calculated compared with a height of 165-170 cm, separately and in combination with (im)mobility. RESULTS: In 4464 patients who reported their height, we found an increasing risk of a first and recurrent event with height. For men, a 2.9-fold (95% confidence interval [CI] 1.9-4.4) increased risk for first venous thrombosis was found for those between 195 and 200 cm and a 3.8-fold (95% CI 1.5-9.8) higher risk for those > 200 cm compared with the reference category. For recurrence risk, the HRs were 1.7 (95% CI 0.8-3.3) and 3.7 (95% CI 1.4-10.0), respectively. For women, a 1.5-fold (95% CI 0.7-3.4) and 3-fold (95% CI 0.9-9.4) increased risk was found for those > 185 cm for first and recurrent venous thrombosis, respectively. For the tallest men and women, a slight additionally increased risk was observed for sedentary lifestyle. CONCLUSIONS: Tall men and women have an increased risk of first and recurrent venous thrombosis, possibly higher in combination with a sedentary lifestyle.
BACKGROUND: Tall people have an increased risk of a first venous thrombosis. Sedentary lifestyle has been shown to act synergistically with body height, especially during long-haul flights. OBJECTIVE: To estimate the relation between height and risk of a first and recurrent venous thrombosis and a possible additional association with a mobile or an immobile lifestyle. METHODS:Patients with a first venous thrombosis and control subjects were included between 1999 and 2004 (MEGA case-control study). Patients were followed for recurrence for an average time of 5.1 years (MEGA follow-up study). Odds ratios and hazard ratios (HRs) per increase of 5 cm were calculated compared with a height of 165-170 cm, separately and in combination with (im)mobility. RESULTS: In 4464 patients who reported their height, we found an increasing risk of a first and recurrent event with height. For men, a 2.9-fold (95% confidence interval [CI] 1.9-4.4) increased risk for first venous thrombosis was found for those between 195 and 200 cm and a 3.8-fold (95% CI 1.5-9.8) higher risk for those > 200 cm compared with the reference category. For recurrence risk, the HRs were 1.7 (95% CI 0.8-3.3) and 3.7 (95% CI 1.4-10.0), respectively. For women, a 1.5-fold (95% CI 0.7-3.4) and 3-fold (95% CI 0.9-9.4) increased risk was found for those > 185 cm for first and recurrent venous thrombosis, respectively. For the tallest men and women, a slight additionally increased risk was observed for sedentary lifestyle. CONCLUSIONS: Tall men and women have an increased risk of first and recurrent venous thrombosis, possibly higher in combination with a sedentary lifestyle.
Authors: N S Roetker; S M Armasu; J S Pankow; P L Lutsey; W Tang; M A Rosenberg; T M Palmer; R F MacLehose; S R Heckbert; M Cushman; M de Andrade; A R Folsom Journal: J Thromb Haemost Date: 2017-06-06 Impact factor: 5.824
Authors: Florence Y Lai; Mintu Nath; Stephen E Hamby; John R Thompson; Christopher P Nelson; Nilesh J Samani Journal: BMC Med Date: 2018-10-25 Impact factor: 8.775