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Literature DB >> 25624328

In vitro assessment of dual drug combinations to inhibit growth of Neisseria gonorrhoeae.

Kevin Pettus¹, Samera Sharpe¹, John R Papp².

Abstract

The development of resistance to first-line antimicrobial therapies has led to recommendations for combination therapies for the treatment of gonorrhea infection. Recent studies have shown the success of combination therapies in treating patients, but few have reported on the in vitro activities of these drug combinations. An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2015 PMID： 25624328 PMCID： PMC4356837 DOI： 10.1128/AAC.04127-14

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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6. The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea.

Authors: Robert D Kirkcaldy; Hillard S Weinstock; Page C Moore; Susan S Philip; Harold C Wiesenfeld; John R Papp; Peter R Kerndt; Shacondra Johnson; Khalil G Ghanem; Edward W Hook
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