Literature DB >> 25622247

The mutational landscape of endometrial cancer.

Bo Hong1, Matthieu Le Gallo1, Daphne W Bell2.   

Abstract

Globally, endometrial carcinoma causes about 74000 deaths annually. Endometrial carcinomas can be classified into several histological subtypes including endometrioid and serous histologies. Over the course of the past two years, a number of studies have decoded the exomes of endometrioid and serous endometrial carcinomas revealing novel somatically mutated genes that are likely to drive their development. Moreover, an integrated genomic analysis of these two histological subtypes by The Cancer Genome Atlas has led to their molecular reclassification into four discrete molecular subgroups. Collectively, these genomic advances set the stage for future biological and clinical studies to determine their relevance for patient care. Published by Elsevier Ltd.

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Year:  2015        PMID： 25622247      PMCID： PMC4476916          DOI： 10.1016/j.gde.2014.12.004

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  35 in total

Review 1.  Improving oncologic outcomes for women with endometrial cancer: realigning our sights.

Authors:  Sean C Dowdy
Journal:  Gynecol Oncol       Date:  2014-02-20       Impact factor: 5.482

2.  A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas.

Authors:  Meghan L Rudd; Jessica C Price; Sarah Fogoros; Andrew K Godwin; Dennis C Sgroi; Maria J Merino; Daphne W Bell
Journal:  Clin Cancer Res       Date:  2011-01-25       Impact factor: 12.531

3.  MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers.

Authors:  S B Simpkins; T Bocker; E M Swisher; D G Mutch; D J Gersell; A J Kovatich; J P Palazzo; R Fishel; P J Goodfellow
Journal:  Hum Mol Genet       Date:  1999-04       Impact factor: 6.150

Review 4.  Genetic testing by cancer site: uterus.

Authors:  Molly S Daniels
Journal:  Cancer J       Date:  2012 Jul-Aug       Impact factor: 3.360

5.  Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.

Authors:  Siming Zhao; Murim Choi; John D Overton; Stefania Bellone; Dana M Roque; Emiliano Cocco; Federica Guzzo; Diana P English; Joyce Varughese; Sara Gasparrini; Ileana Bortolomai; Natalia Buza; Pei Hui; Maysa Abu-Khalaf; Antonella Ravaggi; Eliana Bignotti; Elisabetta Bandiera; Chiara Romani; Paola Todeschini; Renata Tassi; Laura Zanotti; Luisa Carrara; Sergio Pecorelli; Dan-Arin Silasi; Elena Ratner; Masoud Azodi; Peter E Schwartz; Thomas J Rutherford; Amy L Stiegler; Shrikant Mane; Titus J Boggon; Joseph Schlessinger; Richard P Lifton; Alessandro D Santin
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-28       Impact factor: 11.205

6.  Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.

Authors:  Isaac Kinde; Chetan Bettegowda; Yuxuan Wang; Jian Wu; Nishant Agrawal; Ie-Ming Shih; Robert Kurman; Fanny Dao; Douglas A Levine; Robert Giuntoli; Richard Roden; James R Eshleman; Jesus Paula Carvalho; Suely Kazue Nagahashi Marie; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Luis A Diaz
Journal:  Sci Transl Med       Date:  2013-01-09       Impact factor: 17.956

7.  High frequency strand slippage mutations in CTCF in MSI-positive endometrial cancers.

Authors:  Israel Zighelboim; David G Mutch; Amy Knapp; Li Ding; Mingchao Xie; David E Cohn; Paul J Goodfellow
Journal:  Hum Mutat       Date:  2014-01       Impact factor: 4.878

8.  A mutation in POLE predisposing to a multi-tumour phenotype.

Authors:  Anna Rohlin; Theofanis Zagoras; Staffan Nilsson; Ulf Lundstam; Jan Wahlström; Leif Hultén; Tommy Martinsson; Göran B Karlsson; Margareta Nordling
Journal:  Int J Oncol       Date:  2014-04-29       Impact factor: 5.650

9.  Discovery and saturation analysis of cancer genes across 21 tumour types.

Authors:  Michael S Lawrence; Petar Stojanov; Craig H Mermel; James T Robinson; Levi A Garraway; Todd R Golub; Matthew Meyerson; Stacey B Gabriel; Eric S Lander; Gad Getz
Journal:  Nature       Date:  2014-01-05       Impact factor: 49.962

10.  Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers.

Authors:  C A Hamilton; M K Cheung; K Osann; L Chen; N N Teng; T A Longacre; M A Powell; M R Hendrickson; D S Kapp; J K Chan
Journal:  Br J Cancer       Date:  2006-03-13       Impact factor: 7.640
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  15 in total

1.  Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers.

Authors:  Alba Mota; Eva Colás; Pablo García-Sanz; Irene Campoy; Alejandro Rojo-Sebastián; Sonia Gatius; Ángel García; Luis Chiva; Sonsoles Alonso; Antonio Gil-Moreno; Xavier González-Tallada; Berta Díaz-Feijoo; August Vidal; Patrycja Ziober-Malinowska; Marcin Bobiński; Rafael López-López; Miguel Abal; Jaume Reventós; Xavier Matias-Guiu; Gema Moreno-Bueno
Journal:  Mod Pathol       Date:  2016-09-02       Impact factor: 7.842

2.  Use of comprehensive genomic profiling to direct point-of-care management of patients with gynecologic cancers.

Authors:  Lorna Rodriguez-Rodriguez; Kim M Hirshfield; Veronica Rojas; Robert S DiPaola; Darlene Gibbon; Mira Hellmann; Sara Isani; Aliza Leiser; Gregory M Riedlinger; Allison Wagreich; Siraj M Ali; Julia A Elvin; Vincent A Miller; Shridar Ganesan
Journal:  Gynecol Oncol       Date:  2016-04       Impact factor: 5.482

3.  Restoration of microRNA-29c in type I endometrioid cancer reduced endometrial cancer cell growth.

Authors:  Michelle Van Sinderen; Meaghan Griffiths; Ellen Menkhorst; Keith Niven; Evdokia Dimitriadis
Journal:  Oncol Lett       Date:  2019-07-09       Impact factor: 2.967

4.  The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long noncoding RNA DDX11-AS1 through TAF1/TOP2A inhibition.

Authors:  Shuyao Zhang; Hong Jiang; Zhe Xu; Yi Jiang; Yuqi She; Xiaoting Huang; Shanna Feng; Wanying Chen; Shuang Chen; Yun Chen; Guodong Qiu; Shilong Zhong
Journal:  Am J Cancer Res       Date:  2019-10-01       Impact factor: 6.166

Review 5.  Regulation of epithelial-mesenchymal transition in endometrial cancer: connecting PI3K, estrogen signaling, and microRNAs.

Authors:  C N Kent; I K Guttilla Reed
Journal:  Clin Transl Oncol       Date:  2016-02-08       Impact factor: 3.405

6.  Lean Body Weight and Metformin Are Insufficient to Prevent Endometrial Hyperplasia in Mice Harboring Inactivating Mutations in PTEN.

Authors:  David A Iglesias; Qian Zhang; Joseph Celestino; Charlotte C Sun; Melinda S Yates; Rosemarie E Schmandt; Karen H Lu
Journal:  Oncology       Date:  2016-12-09       Impact factor: 2.935

7.  Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.

Authors:  Mitzi Aguilar; He Zhang; Musi Zhang; Brandi Cantarell; Subhransu S Sahoo; Hao-Dong Li; Ileana C Cuevas; Jayanthi Lea; David S Miller; Hao Chen; Wenxin Zheng; Jeffrey Gagan; Elena Lucas; Diego H Castrillon
Journal:  J Pathol       Date:  2021-03-09       Impact factor: 7.996

8.  An update of the classical Bokhman's dualistic model of endometrial cancer.

Authors:  Miłosz Wilczyński; Justyna Danielska; Jacek Wilczyński
Journal:  Prz Menopauzalny       Date:  2016-07-22

9.  Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.

Authors:  Yunyun Jiang; Gabriel G Malouf; Jianping Zhang; Xiaofeng Zheng; Yunxin Chen; Erika J Thompson; John N Weinstein; Ying Yuan; Jean-Philippe Spano; Russell Broaddus; Nizar M Tannir; David Khayat; Karen H Lu; Xiaoping Su
Journal:  Oncotarget       Date:  2015-11-24

10.  The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.

Authors:  William J Gibson; Erling A Hoivik; Mari K Halle; Amaro Taylor-Weiner; Andrew D Cherniack; Anna Berg; Frederik Holst; Travis I Zack; Henrica M J Werner; Kjersti M Staby; Mara Rosenberg; Ingunn M Stefansson; Kanthida Kusonmano; Aaron Chevalier; Karen K Mauland; Jone Trovik; Camilla Krakstad; Marios Giannakis; Eran Hodis; Kathrine Woie; Line Bjorge; Olav K Vintermyr; Jeremiah A Wala; Michael S Lawrence; Gad Getz; Scott L Carter; Rameen Beroukhim; Helga B Salvesen
Journal:  Nat Genet       Date:  2016-06-27       Impact factor: 38.330
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