Literature DB >> 25620902

3D-resolved targeting of photodynamic therapy using temporal focusing.

Christopher J Rowlands1, Jackie Wu1, Sebastien G M Uzel2, Oliver Klein3, Conor L Evans3, Peter T C So4.   

Abstract

A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1 and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.

Entities:  

Keywords:  cancer; photodynamic therapy; temporal focusing; ultrafast amplifier

Year:  2014        PMID： 25620902      PMCID： PMC4301304          DOI： 10.1088/1612-2011/11/11/115605

Source DB:  PubMed          Journal:  Laser Phys Lett        ISSN： 1612-2011            Impact factor:   2.016


  16 in total

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8.  Deaths: leading causes for 2010.

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9.  Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyne.

Authors:  Mamta Khurana; Hazel A Collins; Aliaksandr Karotki; Harry L Anderson; David T Cramb; Brian C Wilson
Journal:  Photochem Photobiol       Date:  2007 Nov-Dec       Impact factor: 3.421

10.  Complete blood vessel occlusion in the chick chorioallantoic membrane using two-photon excitation photodynamic therapy: implications for treatment of wet age-related macular degeneration.

Authors:  Kimberley S Samkoe; Aisling A Clancy; Aliaksandr Karotki; Brian C Wilson; David T Cramb
Journal:  J Biomed Opt       Date:  2007 May-Jun       Impact factor: 3.170
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  1 in total

1.  Wide-field three-photon excitation in biological samples.

Authors:  Christopher J Rowlands; Demian Park; Oliver T Bruns; Kiryl D Piatkevich; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi; Edward S Boyden; Peter Tc So
Journal:  Light Sci Appl       Date:  2017-05-05       Impact factor: 17.782
  1 in total

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