| Literature DB >> 25620893 |
Daniel Austin1, Ian H Dinwoodie2.
Abstract
We describe methods to identify cylinder sets inside a basin of attraction for Boolean dynamics of biological networks. Such sets are used for designing regulatory interventions that make the system evolve towards a chosen attractor, for example initiating apoptosis in a cancer cell. We describe two algebraic methods for identifying cylinders inside a basin of attraction, one based on the Groebner fan that finds monomials that define cylinders and the other on primary decomposition. Both methods are applied to current examples of gene networks.Entities:
Keywords: Apoptosis; Boolean network; Groebner basis; Groebner fan; asynchronous network; basin of attraction; prime decomposition
Year: 2015 PMID: 25620893 PMCID: PMC4299671 DOI: 10.1137/140975929
Source DB: PubMed Journal: SIAM J Appl Dyn Syst ISSN: 1536-0040 Impact factor: 2.316