Literature DB >> 25620893

MONOMIALS AND BASIN CYLINDERS FOR NETWORK DYNAMICS.

Daniel Austin1, Ian H Dinwoodie2.   

Abstract

We describe methods to identify cylinder sets inside a basin of attraction for Boolean dynamics of biological networks. Such sets are used for designing regulatory interventions that make the system evolve towards a chosen attractor, for example initiating apoptosis in a cancer cell. We describe two algebraic methods for identifying cylinders inside a basin of attraction, one based on the Groebner fan that finds monomials that define cylinders and the other on primary decomposition. Both methods are applied to current examples of gene networks.

Entities:  

Keywords:  Apoptosis; Boolean network; Groebner basis; Groebner fan; asynchronous network; basin of attraction; prime decomposition

Year:  2015        PMID: 25620893      PMCID: PMC4299671          DOI: 10.1137/140975929

Source DB:  PubMed          Journal:  SIAM J Appl Dyn Syst        ISSN: 1536-0040            Impact factor:   2.316


  24 in total

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5.  Boolean formalization of genetic control circuits.

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8.  Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.

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9.  Regularity and predictability of human mobility in personal space.

Authors:  Daniel Austin; Robin M Cross; Tamara Hayes; Jeffrey Kaye
Journal:  PLoS One       Date:  2014-02-27       Impact factor: 3.240

Review 10.  Intracellular calcium signalling in Alzheimer's disease.

Authors:  Marina Hermes; Gerhard Eichhoff; Olga Garaschuk
Journal:  J Cell Mol Med       Date:  2009-11-19       Impact factor: 5.310

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  1 in total

1.  COMPUTATIONAL METHODS FOR ASYNCHRONOUS BASINS.

Authors:  Ian H Dinwoodie
Journal:  Discrete Continuous Dyn Syst Ser B       Date:  2016-11-01       Impact factor: 1.327

  1 in total

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