| Literature DB >> 2561974 |
V J Buckle1, N Fujita, A S Ryder-Cook, J M Derry, P J Barnard, R V Lebo, P R Schofield, P H Seeburg, A N Bateson, M G Darlison.
Abstract
Hybridization of GABAA receptor probes to human chromosomes in situ and to DNA from sorted human chromosomes has localized the genes encoding a beta subunit and three isoforms of the alpha subunit. The alpha 2 and beta genes are both located on chromosome 4 in bands p12-p13 and may be adjacent. The alpha 1 gene is on chromosome 5 (bands q34-q35) and the alpha 3 gene is on the X chromosome. The alpha 3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression.Entities:
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Year: 1989 PMID： 2561974 DOI： 10.1016/0896-6273(89)90275-4
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173