Atsuhiko Sugiyama1, Shoichi Ito2, Tomoki Suichi3, Toru Sakurai4, Hiroki Mukai5, Hajime Yokota5, Tadahiro Yonezu3, Satoshi Kuwabara4. 1. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: chinneosyo0624@yahoo.co.jp. 2. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan; Office of Medical Education, Graduate School of Medicine, Chiba University, Chiba, Japan. 3. Department of Neurology, Japanese Red Cross Narita Hospital, Narita, Japan. 4. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. 5. Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Abstract
OBJECTIVE: To identify useful MRI abnormalities in the putamen for diagnosing multiple system atrophy. METHODS: Patients with multiple system atrophy (n=15), Parkinson's disease (n=16), or progressive supranuclear palsy (n=9) and healthy controls (n=10) were enrolled. Using a visual analog scale, 4 examiners independently rated high-intensity signals along the lateral putamen on T2-weighted and T2*-weighted images, low-intensity signals within the putamen on T2-weighted and T2*-weighted images, and putaminal atrophy. Receiver operating characteristic analyses were performed, and the area under the receiver operating characteristic curve was calculated. RESULTS: For differentiating multiple system atrophy from progressive supranuclear palsy, Parkinson's disease, and healthy controls, the mean area under the curve values was the highest for low-intensity signals within the putamen on T2*-weighted images (0.797, 0.867, 0.896, respectively). Variations in the area under the curve values among the 4 examiners were the smallest in low-intensity signals within the putamen on T2*-weighted images. Good inter-rater reliability was achieved for low-intensity signals within the putamen on T2*-weighted images and high-intensity signals along the lateral putamen on T2*-weighted images. CONCLUSION: Low-intensity signals within the putamen on T2*-weighted images is the most useful MRI abnormality for diagnosing multiple system atrophy.
OBJECTIVE: To identify useful MRI abnormalities in the putamen for diagnosing multiple system atrophy. METHODS:Patients with multiple system atrophy (n=15), Parkinson's disease (n=16), or progressive supranuclear palsy (n=9) and healthy controls (n=10) were enrolled. Using a visual analog scale, 4 examiners independently rated high-intensity signals along the lateral putamen on T2-weighted and T2*-weighted images, low-intensity signals within the putamen on T2-weighted and T2*-weighted images, and putaminal atrophy. Receiver operating characteristic analyses were performed, and the area under the receiver operating characteristic curve was calculated. RESULTS: For differentiating multiple system atrophy from progressive supranuclear palsy, Parkinson's disease, and healthy controls, the mean area under the curve values was the highest for low-intensity signals within the putamen on T2*-weighted images (0.797, 0.867, 0.896, respectively). Variations in the area under the curve values among the 4 examiners were the smallest in low-intensity signals within the putamen on T2*-weighted images. Good inter-rater reliability was achieved for low-intensity signals within the putamen on T2*-weighted images and high-intensity signals along the lateral putamen on T2*-weighted images. CONCLUSION: Low-intensity signals within the putamen on T2*-weighted images is the most useful MRI abnormality for diagnosing multiple system atrophy.
Authors: G Carré; J L Dietemann; O Gebus; S Montaut; O Lagha-Boukbiza; T Wirth; S Kremer; I J Namer; M Anheim; C Tranchant Journal: J Neurol Date: 2020-01-14 Impact factor: 4.849