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Literature DB >> 25618328

Ciliary ectosomes: transmissions from the cell's antenna.

Abstract

The cilium is the site of function for a variety of membrane receptors, enzymes and signal transduction modules crucial for a spectrum of cellular processes. Through targeted transport and selective gating mechanisms, the cell localizes specific proteins to the cilium that equip it for the role of sensory antenna. This capacity of the cilium to serve as a specialized compartment where specific proteins can be readily concentrated for sensory reception also makes it an ideal organelle to employ for the regulated emission of specific biological material and information. In this review we present and discuss an emerging body of evidence centered on ciliary ectosomes - bioactive vesicles released from the surface of the cilium.

Entities: CellLine Chemical Disease Gene Species

Keywords: cilium; extracellular vesicles; intercellular signaling

Mesh：

Substances：
Proteins

Year: 2015 PMID： 25618328 PMCID： PMC4409478 DOI： 10.1016/j.tcb.2014.12.008

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

118 in total

1. An ocular study of pulseless disease.

Authors: J L DOWLING; T R SMITH
Journal: Arch Ophthalmol Date: 1960-08

Review 2. Cellular deflagellation.

Authors: Lynne M Quarmby
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3. Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.

Authors: A Ginestra; S Monea; G Seghezzi; V Dolo; H Nagase; P Mignatti; M L Vittorelli
Journal: J Biol Chem Date: 1997-07-04 Impact factor: 5.157

4. Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein.

Authors: D Corbeil; C A Fargeas; W B Huttner
Journal: Biochem Biophys Res Commun Date: 2001-07-27 Impact factor: 3.575

Review 5. Microvesicles as mediators of intercellular communication in cancer--the emerging science of cellular 'debris'.

Authors: Tae Hoon Lee; Esterina D'Asti; Nathalie Magnus; Khalid Al-Nedawi; Brian Meehan; Janusz Rak
Journal: Semin Immunopathol Date: 2011-02-12 Impact factor: 9.623

Review 6. The vertebrate primary cilium is a sensory organelle.

Authors: Gregory J Pazour; George B Witman
Journal: Curr Opin Cell Biol Date: 2003-02 Impact factor: 8.382

Review 7. Mechanics of dynamin-mediated membrane fission.

Authors: Sandrine Morlot; Aurélien Roux
Journal: Annu Rev Biophys Date: 2013 Impact factor: 12.981

8. Participation of the retinal pigment epithelium in the rod outer segment renewal process.

Authors: R W Young; D Bok
Journal: J Cell Biol Date: 1969-08 Impact factor: 10.539

9. The renewal of protein in retinal rods and cones.

Authors: R W Young; B Droz
Journal: J Cell Biol Date: 1968-10 Impact factor: 10.539

10. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.

Authors: G J Pazour; B L Dickert; Y Vucica; E S Seeley; J L Rosenbaum; G B Witman; D G Cole
Journal: J Cell Biol Date: 2000-10-30 Impact factor: 10.539

57 in total

Review 1. Mechanism of ciliary disassembly.

Authors: Yinwen Liang; Dan Meng; Bing Zhu; Junmin Pan
Journal: Cell Mol Life Sci Date: 2016-02-11 Impact factor: 9.261

2. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Authors: Siew Cheng Phua; Shuhei Chiba; Masako Suzuki; Emily Su; Elle C Roberson; Ganesh V Pusapati; Stéphane Schurmans; Mitsutoshi Setou; Rajat Rohatgi; Jeremy F Reiter; Koji Ikegami; Takanari Inoue
Journal: Cell Date: 2017-01-12 Impact factor: 41.582

3. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis.

Authors: Juan Wang; Rachel Kaletsky; Malan Silva; April Williams; Leonard A Haas; Rebecca J Androwski; Jessica N Landis; Cory Patrick; Alina Rashid; Dianaliz Santiago-Martinez; Maria Gravato-Nobre; Jonathan Hodgkin; David H Hall; Coleen T Murphy; Maureen M Barr
Journal: Curr Biol Date: 2015-12-10 Impact factor: 10.834

Ciliary ectosomes: transmissions from the cell's antenna.

1. An ocular study of pulseless disease.

Review 2. Cellular deflagellation.

3. Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.

4. Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein.

Review 5. Microvesicles as mediators of intercellular communication in cancer--the emerging science of cellular 'debris'.

Review 6. The vertebrate primary cilium is a sensory organelle.

Review 7. Mechanics of dynamin-mediated membrane fission.

8. Participation of the retinal pigment epithelium in the rod outer segment renewal process.

9. The renewal of protein in retinal rods and cones.

10. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.

Review 1. Mechanism of ciliary disassembly.

2. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

3. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis.

Review 4. Model Organisms in G Protein-Coupled Receptor Research.

Review 5. Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections.

6. Three-dimensional architecture of epithelial primary cilia.

Review 7. Routes and machinery of primary cilium biogenesis.

Review 8. Neuron's little helper: The role of primary cilia in neurogenesis.

Review 9. Extracellular Vesicles: Unique Intercellular Delivery Vehicles.

Review 10. Cellular signalling by primary cilia in development, organ function and disease.