Literature DB >> 26925800

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.

Allison S Brandt1, Paul G Unschuld2, Subechhya Pradhan3, Issel Anne L Lim3, Gregory Churchill1, Ashley D Harris3, Jun Hua3, Peter B Barker3, Christopher A Ross4, Peter C M van Zijl3, Richard A E Edden3, Russell L Margolis5.   

Abstract

The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  7T; Anterior cingulate cortex; Glutamate; Magnetic resonance spectroscopy; Schizophrenia

Mesh：

Substances：

Year:  2016        PMID： 26925800      PMCID： PMC4821673          DOI： 10.1016/j.schres.2016.02.017

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  72 in total

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Review 5.  A meta-analysis of ultra-high field glutamate, glutamine, GABA and glutathione 1HMRS in psychosis: Implications for studies of psychosis risk.

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9.  7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.

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