Literature DB >> 25614099

Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone.

I Kviatkovski1, L Chernin, T Yarnitzky, I Frumin, N Sobel, Y Helman.   

Abstract

In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

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Year:  2015        PMID： 25614099     DOI： 10.1039/c4cc10393a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation.

Authors:  Sizhe Li; Julien Wawrzyniak; Yves Queneau; Laurent Soulère
Journal:  Molecules       Date:  2017-11-29       Impact factor: 4.411

2.  Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.

Authors:  Sara Skøtt Paulsen; Thomas Isbrandt; Markus Kirkegaard; Yannick Buijs; Mikael Lenz Strube; Eva C Sonnenschein; Thomas O Larsen; Lone Gram
Journal:  Sci Rep       Date:  2020-12-10       Impact factor: 4.379

Review 3.  Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa.

Authors:  Telma de Sousa; Michel Hébraud; Maria L N Enes Dapkevicius; Luís Maltez; José Eduardo Pereira; Rosa Capita; Carlos Alonso-Calleja; Gilberto Igrejas; Patricia Poeta
Journal:  Int J Mol Sci       Date:  2021-11-29       Impact factor: 5.923

4.  Thriving Under Stress: Pseudomonas aeruginosa Outcompetes the Background Polymicrobial Community Under Treatment Conditions in a Novel Chronic Wound Model.

Authors:  Joann Phan; Saba Ranjbar; Miki Kagawa; Matthew Gargus; Allon Israel Hochbaum; Katrine L Whiteson
Journal:  Front Cell Infect Microbiol       Date:  2020-10-06       Impact factor: 5.293
  4 in total

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