Literature DB >> 25612113

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications.

Patricia M R Pereira1, Barbara Korsak, Bruno Sarmento, Rudolf J Schneider, Rosa Fernandes, João P C Tomé.   

Abstract

Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.

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Year:  2015        PMID： 25612113     DOI： 10.1039/c4ob02334j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  13 in total

1.  Alternatives to the 'water oxidation pathway' of biological ozone formation.

Authors:  Arnold N Onyango
Journal:  J Chem Biol       Date:  2015-06-16

2.  Emerging applications of porphyrins in photomedicine.

Authors:  Haoyuan Huang; Wentao Song; James Rieffel; Jonathan F Lovell
Journal:  Front Phys       Date:  2015-04-10

3.  Facile synthesis of chlorin bioconjugates by a series of click reactions.

Authors:  Junior Gonzales; N V S Dinesh K Bhupathiraju; William Perea; Huong Chu; Naxhije Berisha; Veronica Bueno; Naser Dodic; Julia Rozenberg; Nancy L Greenbaum; Charles Michael Drain
Journal:  Chem Commun (Camb)       Date:  2017-03-28       Impact factor: 6.222

4.  One-Pot Synthesis of Four Chlorin Derivatives by a Divergent Ylide.

Authors:  Junior Gonzales; N V S Dinesh K Bhupathiraju; Daniel Hart; Man Yuen; Maria Pia Sifuentes; Bleron Samarxhiu; Mark Maranan; Naxhije Berisha; James Batteas; Charles Michael Drain
Journal:  J Org Chem       Date:  2018-05-29       Impact factor: 4.354

Review 5.  Photodynamic Therapy and the Biophysics of the Tumor Microenvironment.

Authors:  Aaron J Sorrin; Mustafa Kemal Ruhi; Nathaniel A Ferlic; Vida Karimnia; William J Polacheck; Jonathan P Celli; Huang-Chiao Huang; Imran Rizvi
Journal:  Photochem Photobiol       Date:  2020-03-05       Impact factor: 3.421

Review 6.  Photodynamic viral inactivation: Recent advances and potential applications.

Authors:  Jace A Willis; Vsevolod Cheburkanov; Giulia Kassab; Jennifer M Soares; Kate C Blanco; Vanderlei S Bagnato; Vladislav V Yakovlev
Journal:  Appl Phys Rev       Date:  2021-06       Impact factor: 19.162

7.  Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.

Authors:  R Dondi; E Yaghini; K M Tewari; L Wang; F Giuntini; M Loizidou; A J MacRobert; I M Eggleston
Journal:  Org Biomol Chem       Date:  2016-12-07       Impact factor: 3.876

8.  Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.

Authors:  David R Chisholm; Rebecca Lamb; Tommy Pallett; Valerie Affleck; Claire Holden; Joanne Marrison; Peter O'Toole; Peter D Ashton; Katherine Newling; Andreas Steffen; Amanda K Nelson; Christoph Mahler; Roy Valentine; Thomas S Blacker; Angus J Bain; John Girkin; Todd B Marder; Andrew Whiting; Carrie A Ambler
Journal:  Chem Sci       Date:  2019-03-21       Impact factor: 9.825

9.  Structural Investigations, Cellular Imaging, and Radiolabeling of Neutral, Polycationic, and Polyanionic Functional Metalloporphyrin Conjugates.

Authors:  Valeria Ciaffaglione; Philip A Waghorn; Rüdiger M Exner; Fernando Cortezon-Tamarit; Samuel P Godfrey; Sophia Sarpaki; Helena Quilter; Ruggero Dondi; Haobo Ge; Gabriele Kociok-Kohn; Stanley W Botchway; Ian M Eggleston; Jonathan R Dilworth; Sofia I Pascu
Journal:  Bioconjug Chem       Date:  2021-02-01       Impact factor: 4.774

10.  Toxicological and efficacy assessment of post-transition metal (Indium) phthalocyanine for photodynamic therapy in neuroblastoma.

Authors:  Monica Neagu; Carolina Constantin; Mircea Tampa; Clara Matei; Andreea Lupu; Emilia Manole; Rodica-Mariana Ion; Concettina Fenga; Aristidis M Tsatsakis
Journal:  Oncotarget       Date:  2016-10-25
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