Literature DB >> 25611779

Is sentinel node susceptibility to metastases related to nodal immune modulation?

Alistair J Cochran1, Rong-Rong Huang, Albert Su, Eijun Itakura, Duan-Ren Wen.   

Abstract

Sentinel lymph nodes (SLNs), the initial site of regional metastases, directly receive lymph containing immune-modulatory cytokines and tumor cells from primary melanomas. Immune-suppressed SLNs are ideal for studies of tissue susceptibility to metastases. They show reduced antigen-presenting dendritic cells, activated T cells, high endothelial venules, and transvenular immigration of T cells. Tumor-induced immune suppression contributes to establishment of nodal metastases. SLNs may serve as an effective model to study reversal of tumor-induced immune suppression. We reviewed this topic in Nature Reviews of Immunology in 2006. We here summarize the Nature paper and provide additional results from ongoing studies and the recent literature.

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Year:  2015        PMID： 25611779     DOI： 10.1097/PPO.0000000000000094

Source DB:  PubMed          Journal:  Cancer J        ISSN： 1528-9117            Impact factor:   3.360


  10 in total

1.  Detection of melanoma metastases with the sentinel node biopsy: the legacy of Donald L. Morton, MD (1934-2014).

Authors:  Charles M Balch
Journal:  Clin Exp Metastasis       Date:  2018-05-31       Impact factor: 5.150

Review 2.  The lymph node pre-metastatic niche.

Authors:  Jonathan P Sleeman
Journal:  J Mol Med (Berl)       Date:  2015-11       Impact factor: 4.599

Review 3.  Clinical utilities and biological characteristics of melanoma sentinel lymph nodes.

Authors:  Dale Han; Daniel C Thomas; Jonathan S Zager; Barbara Pockaj; Richard L White; Stanley Pl Leong
Journal:  World J Clin Oncol       Date:  2016-04-10

Review 4.  Reprogramming of sentinel lymph node microenvironment during tumor metastasis.

Authors:  Yen-Liang Li; Wen-Chun Hung
Journal:  J Biomed Sci       Date:  2022-10-20       Impact factor: 12.771

5.  Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area.

Authors:  A Marijne Heeren; Eline de Boer; Maaike C G Bleeker; René J P Musters; Marrije R Buist; Gemma G Kenter; Tanja D de Gruijl; Ekaterina S Jordanova
Journal:  Oncotarget       Date:  2015-10-20

6.  microRNA Expression in Sentinel Nodes from Progressing Melanoma Patients Identifies Networks Associated with Dysfunctional Immune Response.

Authors:  Viviana Vallacchi; Chiara Camisaschi; Matteo Dugo; Elisabetta Vergani; Paola Deho; Ambra Gualeni; Veronica Huber; Annunziata Gloghini; Andrea Maurichi; Mario Santinami; Marialuisa Sensi; Chiara Castelli; Licia Rivoltini; Monica Rodolfo
Journal:  Genes (Basel)       Date:  2016-12-14       Impact factor: 4.096

7.  Aggressive rat prostate tumors reprogram the benign parts of the prostate and regional lymph nodes prior to metastasis.

Authors:  Kerstin Strömvall; Elin Thysell; Sofia Halin Bergström; Anders Bergh
Journal:  PLoS One       Date:  2017-05-04       Impact factor: 3.240

8.  Reduced number of CD169+ macrophages in pre-metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients.

Authors:  Kerstin Strömvall; Kristoffer Sundkvist; Börje Ljungberg; Sofia Halin Bergström; Anders Bergh
Journal:  Prostate       Date:  2017-09-07       Impact factor: 4.104

9.  Highly aggressive rat prostate tumors rapidly precondition regional lymph nodes for subsequent metastatic growth.

Authors:  Kerstin Strömvall; Marie Lundholm; Elin Thysell; Anders Bergh; Sofia Halin Bergström
Journal:  PLoS One       Date:  2017-10-26       Impact factor: 3.240

Review 10.  The pre-metastatic niche in lymph nodes: formation and characteristics.

Authors:  Lionel Gillot; Louis Baudin; Loïc Rouaud; Frédéric Kridelka; Agnès Noël
Journal:  Cell Mol Life Sci       Date:  2021-07-09       Impact factor: 9.261
  10 in total

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