Literature DB >> 25605726

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.

Nikoleta G Tsvetanova1, Roshanak Irannejad1, Mark von Zastrow2.   

Abstract

Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Keywords:  Cell Signaling; Cyclic AMP (cAMP); Endocytosis; Endosome; G Protein; G Protein-coupled Receptor (GPCR); Protein Sorting; Signal Transduction; Transcription

Mesh：

Substances：

Year:  2015        PMID： 25605726      PMCID： PMC4358092          DOI： 10.1074/jbc.R114.617951

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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