Sukamal Saha1, Mohammed Shaik2, Gregory Johnston3, Supriya Kumar Saha4, Lindsay Berbiglia5, Micheal Hicks5, Jill Gernand5, Sandeep Grewal6, Madan Arora6, David Wiese7. 1. Department of Surgery, McLaren Regional Medical Center, Flint, MI 48532, USA. Electronic address: ssahadr@aol.com. 2. Division of Hematology/Oncology, Michigan State University, East Lansing, MI, USA. 3. Department of Surgery, McLaren Macomb, Mount Clemens, MI, USA. 4. Department of Hematology/Oncology, Massachusettes General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. 5. Department of Surgery, McLaren Regional Medical Center, Flint, MI 48532, USA. 6. McLaren Regional Medical Center, Department of Hematology/Oncology, Flint, MI 48532, USA. 7. McLaren Regional Medical Center, Department of Pathology, Flint, MI 48532, USA.
Abstract
BACKGROUND: American Joint Committee on Cancer uses tumor size for "T" staging of many solid tumors for its effect on prognosis. However, tumor size has not been incorporated in tumor (T), nodal status (N), metastasis (M) staging for colon cancer. Hence, the National Cancer Data Base was used to determine whether tumor size correlates with TNM staging and survival. METHODS: For the 300,386 patients, tumor size was divided into S1 (0 to 2 cm), S2 (>2 to 4 cm), S3 (>4 to 6 cm), and S4 (>6 cm). Statistical comparison was done for TNM stage, grade, and nodal status with tumor size. Kaplan-Meier survival analysis was done for each "S" stage. RESULTS: Of the 300,386 patients, 13% were classified as S1, 39% S2, 30% S3 and 18% as S4. Right colon was the most common site (48%). Tumor size positively correlated with grade, T stage, and nodal stage. Tumor size was inversely associated with survival. CONCLUSION: Tumor size is positively correlated with important prognostic factors and negatively impacted survival.
BACKGROUND: American Joint Committee on Cancer uses tumor size for "T" staging of many solid tumors for its effect on prognosis. However, tumor size has not been incorporated in tumor (T), nodal status (N), metastasis (M) staging for colon cancer. Hence, the National Cancer Data Base was used to determine whether tumor size correlates with TNM staging and survival. METHODS: For the 300,386 patients, tumor size was divided into S1 (0 to 2 cm), S2 (>2 to 4 cm), S3 (>4 to 6 cm), and S4 (>6 cm). Statistical comparison was done for TNM stage, grade, and nodal status with tumor size. Kaplan-Meier survival analysis was done for each "S" stage. RESULTS: Of the 300,386 patients, 13% were classified as S1, 39% S2, 30% S3 and 18% as S4. Right colon was the most common site (48%). Tumor size positively correlated with grade, T stage, and nodal stage. Tumor size was inversely associated with survival. CONCLUSION:Tumor size is positively correlated with important prognostic factors and negatively impacted survival.
Authors: Erika L Garcia-Villatoro; Jennifer A A DeLuca; Evelyn S Callaway; Kimberly F Allred; Laurie A Davidson; Martha E Hensel; Rani Menon; Ivan Ivanov; Stephen H Safe; Arul Jayaraman; Robert S Chapkin; Clinton D Allred Journal: Am J Physiol Gastrointest Liver Physiol Date: 2020-01-06 Impact factor: 4.052