Daniel Dalla Torre1, Doris Burtscher2, Michael Edlinger3, Elisabeth Sölder4, Andreas Widschwendter4, Michael Rasse5, Wolfgang Puelacher5. 1. University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria; Dental Clinic Dalla Torre, Jaufenstrasse, Sterzing, Italy. Electronic address: dr.dalla-torre@gmx.at. 2. University Clinic of Prosthodontics, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria. 3. Department of Medical Statistics, Informatics and Health Economics, Medical University Innsbruck, Schöpfstrasse, Innsbruck, Austria. 4. University Clinic of Obstetrics and Gynecology, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria. 5. University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
Abstract
OBJECTIVE: The role of human papilloma virus (HPV) infections in oral carcinogenesis is an important topic of research in maxillofacial oncology. Nevertheless, the association between such infections in the oral cavity and the development of oral precancerous lesions remains unclear. The aim of this study was to evaluate the association between oral HPV infections and oral leukoplakia or erythroplakia. STUDY DESIGN: The case control study included 118 patients with manifest oral leukoplakia or erythroplakia, who underwent surgical biopsy, including a histopathologic grading of the lesion, and 100 control patients without any oral lesions. HPV detection was achieved with a noninvasive brush smear method (Digene Cervical Sampler, Hybrid Capture II-Test). Logistic regression analysis was performed to assess the associations. RESULTS: A significant association was found between high-risk oral HPV infection and the presence of oral premalignant lesions (P = .001). Among all other evaluated parameters, only smoking showed a significant association with the presence of oral lesions. CONCLUSIONS: Oral HPV infections may play a role in the pathogenesis of premalignant oral lesions.
OBJECTIVE: The role of human papilloma virus (HPV) infections in oral carcinogenesis is an important topic of research in maxillofacial oncology. Nevertheless, the association between such infections in the oral cavity and the development of oral precancerous lesions remains unclear. The aim of this study was to evaluate the association between oral HPV infections and oral leukoplakia or erythroplakia. STUDY DESIGN: The case control study included 118 patients with manifest oral leukoplakia or erythroplakia, who underwent surgical biopsy, including a histopathologic grading of the lesion, and 100 control patients without any oral lesions. HPV detection was achieved with a noninvasive brush smear method (Digene Cervical Sampler, Hybrid Capture II-Test). Logistic regression analysis was performed to assess the associations. RESULTS: A significant association was found between high-risk oral HPV infection and the presence of oral premalignant lesions (P = .001). Among all other evaluated parameters, only smoking showed a significant association with the presence of oral lesions. CONCLUSIONS: Oral HPV infections may play a role in the pathogenesis of premalignant oral lesions.
Authors: Anne S Tsao; Vassiliki Papadimitrakopoulou; Heather Lin; Ming Guo; J Jack Lee; F Christopher Holsinger; Waun Ki Hong; Erich M Sturgis Journal: Infect Agent Cancer Date: 2016-04-27 Impact factor: 2.965