Literature DB >> 25598195

The sensitivity to change over time of the Amsterdam IADL Questionnaire(©).

Naomi Koster1, Dirk L Knol2, Bernard M J Uitdehaag3, Philip Scheltens4, Sietske A M Sikkes5.   

Abstract

INTRODUCTION: This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire(©) (A-IADL-Q).
METHODS: Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures.
RESULTS: We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028). DISCUSSION: Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Dementia; Instrumental activities of daily living; Mild cognitive impairment; Responsiveness; Subjective cognitive decline

Mesh：

Year:  2015        PMID： 25598195     DOI： 10.1016/j.jalz.2014.10.006

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN： 1552-5260            Impact factor:   21.566


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