Charlotte K Ekelund1, Olav B Petersen2, Finn S Jørgensen3,4, Susanne Kjaergaard5, Torben Larsen6, Annette W Olesen7, Lillian Skibsted4,8, Peter Skovbo9, Steffen Sommer10, Lene Sperling11, Benedicte Stavnstrup1, Birgitte Størup12, Helle Zingenberg13, Niels Uldbjerg2, Caroline B Miltoft1, Lasse Noergaard14, Camilla B Wulff1, Ann Tabor1,4. 1. Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 2. Fetal Medicine Unit, Department of Obstetrics, Aarhus University Hospital, Skejby, Denmark. 3. Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark. 4. Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark. 5. Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark. 6. Departments of Gynecology and Obstetrics, Holbaek Hospital, Holbaek, Denmark. 7. Kolding Hospital, Kolding, Denmark. 8. Roskilde Hospital, Roskilde, Denmark. 9. Aalborg Hospital, Aalborg, Denmark. 10. Horsens Hospital, Horsens, Denmark. 11. Odense University Hospital, Odense, Denmark. 12. Hjoerring Hospital, Hjoerring, Denmark. 13. Fetal Medicine Unit, Department of Gynecology and Obstetrics, Herlev Hospital, Copenhagen, Denmark. 14. Unit for Clinical Information and Data, Capitol Region, Copenhagen, Denmark.
Abstract
OBJECTIVE: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012. DESIGN: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database. POPULATION: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21. METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved. MAIN OUTCOME MEASURES: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates. RESULTS: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period. CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.
OBJECTIVE: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012. DESIGN: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database. POPULATION: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21. METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved. MAIN OUTCOME MEASURES: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates. RESULTS: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period. CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.
Authors: Karuna R M van der Meij; Erik A Sistermans; Merryn V E Macville; Servi J C Stevens; Caroline J Bax; Mireille N Bekker; Caterina M Bilardo; Elles M J Boon; Marjan Boter; Karin E M Diderich; Christine E M de Die-Smulders; Leonie K Duin; Brigitte H W Faas; Ilse Feenstra; Monique C Haak; Mariëtte J V Hoffer; Nicolette S den Hollander; Iris H I M Hollink; Fernanda S Jehee; Maarten F C M Knapen; Angelique J A Kooper; Irene M van Langen; Klaske D Lichtenbelt; Ingeborg H Linskens; Merel C van Maarle; Dick Oepkes; Mijntje J Pieters; G Heleen Schuring-Blom; Esther Sikkel; Birgit Sikkema-Raddatz; Dominique F C M Smeets; Malgorzata I Srebniak; Ron F Suijkerbuijk; Gita M Tan-Sindhunata; A Jeanine E M van der Ven; Shama L van Zelderen-Bhola; Lidewij Henneman; Robert-Jan H Galjaard; Diane Van Opstal; Marjan M Weiss Journal: Am J Hum Genet Date: 2019-11-07 Impact factor: 11.025
Authors: Lars H Pedersen; Olav B Petersen; Mette Nørgaard; Charlotte Ekelund; Lars Pedersen; Ann Tabor; Henrik T Sørensen Journal: Clin Epidemiol Date: 2016-05-11 Impact factor: 4.790
Authors: Charlotte Rosenkrantz Bodin; Mikkel Mylius Rasmussen; Ann Tabor; Lena Westbom; Eleonor Tiblad; Charlotte Kvist Ekelund; Camilla Bernt Wulff; Ida Vogel; Olav Bjørn Petersen Journal: Biomed Res Int Date: 2018-02-01 Impact factor: 3.411