Literature DB >> 25595555

Are RNAi and miRNA therapeutics truly dead?

João Conde1, Natalie Artzi2.   

Abstract

Only a few years ago pharmaceutical companies were excited about the potential of RNA interference (RNAi). Now, financial volatility and subsequent dissolutions of in-house facilities by pharmaceutical companies have had media channels pronouncing that RNAi therapeutics are dead. However, advances in nanomedicine may now help the vast potential of RNAi therapeutics to be fulfilled.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords:  RNAi; biomaterials; delivery vehicle; nanotechnology; pharmaceutical companies

Mesh:

Substances:

Year:  2015        PMID: 25595555     DOI: 10.1016/j.tibtech.2014.12.005

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN: 0167-7799            Impact factor:   19.536


  20 in total

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Review 2.  MicroRNAs in glaucoma and neurodegenerative diseases.

Authors:  Milena Molasy; Anna Walczak; Jerzy Szaflik; Jacek P Szaflik; Ireneusz Majsterek
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3.  The effector mechanism of siRNA spherical nucleic acids.

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Review 4.  Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities.

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5.  MiR181c inhibits ovarian cancer metastasis and progression by targeting PRKCD expression.

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Review 7.  Oral nucleic acid therapy using multicompartmental delivery systems.

Authors:  Husain Attarwala; Murui Han; Jonghan Kim; Mansoor Amiji
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2017-05-24

Review 8.  Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Authors:  Philipp M Cromm; Craig M Crews
Journal:  Cell Chem Biol       Date:  2017-06-22       Impact factor: 8.116

9.  Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers.

Authors:  Ao Yu; Siyuan Tang; Ling Ding; Jackson Foley; Weimin Tang; Huizhen Jia; Sudipta Panja; Cassandra E Holbert; Yu Hang; Tracy Murray Stewart; Lynette M Smith; Diptesh Sil; Robert A Casero; David Oupický
Journal:  Biomater Adv       Date:  2022-03-17

Review 10.  Ki67 targeted strategies for cancer therapy.

Authors:  C Yang; J Zhang; M Ding; K Xu; L Li; L Mao; J Zheng
Journal:  Clin Transl Oncol       Date:  2017-10-20       Impact factor: 3.340

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