OBJECTIVE: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). DESIGN: The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. SETTING: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. SUBJECTS: Studies involved samples of people of all ages. RESULTS: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95% CI 0·90, 0·97). CONCLUSIONS: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.
OBJECTIVE: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). DESIGN: The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. SETTING: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. SUBJECTS: Studies involved samples of people of all ages. RESULTS: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95% CI 0·90, 0·97). CONCLUSIONS: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.
Entities:
Keywords:
Age-related cataract; Meta-analysis; Serum tocopherol; Vitamin E
Authors: Manfred Eggersdorfer; Ucheoma Akobundu; Regan L Bailey; Julie Shlisky; Amy R Beaudreault; Gilles Bergeron; Robert B Blancato; Jeffrey B Blumberg; Megan W Bourassa; Filomena Gomes; Gordon Jensen; Mary Ann Johnson; Douglas Mackay; Keri Marshall; Simin Nikbin Meydani; Katherine L Tucker Journal: Nutrients Date: 2018-09-01 Impact factor: 5.717