María L Camacho-Barcia1, Mònica Bulló2, Jesús F Garcia-Gavilán1, Miguel Ruiz-Canela3, Dolores Corella4, Ramón Estruch5, Montserrat Fitó6, Alfredo García-Layana7, Fernando Arós8, Miquel Fiol9, José Lapetra10, Lluis Serra-Majem11, Xavier Pintó12, Ana García-Arellano13, Ernest Vinyoles6, José Vicente Sorli4, Jordi Salas-Salvadó2. 1. Human Nutrition Unit, Biochemistry and Biotechnology Department, University Hospital of Sant Joan de Reus, Reus, Spain. 2. Human Nutrition Unit, Biochemistry and Biotechnology Department, University Hospital of Sant Joan de Reus, Reus, Spain2Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain. 3. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain3Department of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain. 4. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain4Department of Preventive Medicine, University of Valencia, Valencia, Spain. 5. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain5Department of Internal Medicine, August Pi i Sunyer Institute of Biomedical Research, Hospital Clinic, University of Barcelona, Barcelona, Spain. 6. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain6Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute, Barcelona Biomedical Research Park, Barcelona, Spain. 7. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain7Department of Ophthalmology, University of Navarra, Pamplona, Spain. 8. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain8Department of Cardiology, Hospital Txangorritxu, Vitoria, Spain. 9. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain9Department of Cardiology, Hospital Universitario Son Dureta, Palma de Mallorca, Spain. 10. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain10San Pablo Health Center, Sevilla, Spain. 11. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain11Research Institut of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain. 12. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain12Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain. 13. Centro de Investigación Biomédica en Red Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain3Department of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain13Emergency Department, Complejo Hospitalario de Navarra, Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
Abstract
Importance: Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging. The exact mechanisms underlying cataract formation are still unclear, but growing evidence suggests a potential role of inflammatory and oxidative processes. Therefore, antioxidant and anti-inflammatory factors of the diet, such as vitamin K1, could play a protective role. Objective: To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population. Design, Setting, and Participants: A prospective analysis was conducted in 5860 participants from the Prevención con Dieta Mediterránea Study, a randomized clinical trial executed between 2003 and 2011. Participants were community-dwelling men (44.2%) and women (55.8%), and the mean (SD) age was 66.3 (6.1) years. Main Outcomes and Measures: Dietary vitamin K1 intake was evaluated using a validated food frequency questionnaire. The time to the cataract event was calculated as the time between recruitment and the date of the occurrence to cataract surgery, the time to the last visit of the follow-up, date of death, or the end of the study. Hazard ratios and 95% CIs for cataract incidence were estimated with a multivariable Cox proportional hazards model. Results:Participants were community-dwelling men (44.2%; n = 868) and women (55.8%; n = 1086), and the mean (SD) age was 66.3 (6.1) years. After a median of 5.6 years follow-up, we documented a total of 768 new cataracts. Participants in the highest tertile of dietary vitamin K1 intake had a lower risk of cataracts than those in the lowest tertile (hazard ratio, 0.71; 95% CI, 0.58-0.88; P = .002), after adjusting for potential confounders. Conclusions and Relevance: High intake of dietary vitamin K1 was associated with a reduced risk of cataracts in an elderly Mediterranean population even after adjusting by other potential confounders. Trial Registration: isrctn.org: ISRCTN35739639.
RCT Entities:
Importance: Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging. The exact mechanisms underlying cataract formation are still unclear, but growing evidence suggests a potential role of inflammatory and oxidative processes. Therefore, antioxidant and anti-inflammatory factors of the diet, such as vitamin K1, could play a protective role. Objective: To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population. Design, Setting, and Participants: A prospective analysis was conducted in 5860 participants from the Prevención con Dieta Mediterránea Study, a randomized clinical trial executed between 2003 and 2011. Participants were community-dwelling men (44.2%) and women (55.8%), and the mean (SD) age was 66.3 (6.1) years. Main Outcomes and Measures: Dietary vitamin K1 intake was evaluated using a validated food frequency questionnaire. The time to the cataract event was calculated as the time between recruitment and the date of the occurrence to cataract surgery, the time to the last visit of the follow-up, date of death, or the end of the study. Hazard ratios and 95% CIs for cataract incidence were estimated with a multivariable Cox proportional hazards model. Results:Participants were community-dwelling men (44.2%; n = 868) and women (55.8%; n = 1086), and the mean (SD) age was 66.3 (6.1) years. After a median of 5.6 years follow-up, we documented a total of 768 new cataracts. Participants in the highest tertile of dietary vitamin K1 intake had a lower risk of cataracts than those in the lowest tertile (hazard ratio, 0.71; 95% CI, 0.58-0.88; P = .002), after adjusting for potential confounders. Conclusions and Relevance: High intake of dietary vitamin K1 was associated with a reduced risk of cataracts in an elderly Mediterranean population even after adjusting by other potential confounders. Trial Registration: isrctn.org: ISRCTN35739639.
Authors: Miguel Ángel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Emilio Ros; María Isabel Covas; Miquel Fiol; Julia Wärnberg; Fernando Arós; Valentina Ruíz-Gutiérrez; Rosa María Lamuela-Raventós; Jose Lapetra; Miguel Ángel Muñoz; José Alfredo Martínez; Guillermo Sáez; Lluis Serra-Majem; Xavier Pintó; María Teresa Mitjavila; Josep Antoni Tur; María Del Puy Portillo; Ramón Estruch Journal: Int J Epidemiol Date: 2010-12-20 Impact factor: 7.196
Authors: C W Thane; C J Bates; M J Shearer; N Unadkat; D J Harrington; A A Paul; A Prentice; C Bolton-Smith Journal: Br J Nutr Date: 2002-06 Impact factor: 3.718
Authors: Joan D Fernández-Ballart; Josep Lluís Piñol; Itziar Zazpe; Dolores Corella; Paula Carrasco; Estefanía Toledo; Manuel Perez-Bauer; Miguel Angel Martínez-González; Jorge Salas-Salvadó; José M Martín-Moreno Journal: Br J Nutr Date: 2010-01-27 Impact factor: 3.718