| Literature DB >> 6087456 |
J D Levine, W Lau, G Kwiat, E J Goetzl.
Abstract
Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.Entities:
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Year: 1984 PMID: 6087456 DOI: 10.1126/science.6087456
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728