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Literature DB >> 25589953

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition.

D S Chu¹, D L Sellers², M J Bocek¹, A E Fischedick², P J Horner², S H Pun¹.

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25589953 PMCID： PMC4289632 DOI： 10.1039/C4BM00259H

Source DB: PubMed Journal: Biomater Sci ISSN： 2047-4830 Impact factor: 6.843

21 in total

1. Substrate hydrolysis by matrix metalloproteinase-9.

Authors: S J Kridel; E Chen; L P Kotra; E W Howard; S Mobashery; J W Smith
Journal: J Biol Chem Date: 2001-03-14 Impact factor: 5.157

2. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

Authors: Drew L Sellers; Tae Hee Kim; Christopher W Mount; Suzie H Pun; Philip J Horner
Journal: Biomaterials Date: 2014-07-23 Impact factor: 12.479

3. Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury.

Authors: B A Citron; I V Smirnova; P M Arnold; B W Festoff
Journal: J Neurotrauma Date: 2000-12 Impact factor: 5.269

4. Thrombin may contribute to the pathophysiology of central nervous system injury.

Authors: A Nishino; M Suzuki; H Ohtani; O Motohashi; K Umezawa; H Nagura; T Yoshimoto
Journal: J Neurotrauma Date: 1993 Impact factor: 5.269

Review 5. Functional regeneration beyond the glial scar.

Authors: Jared M Cregg; Marc A DePaul; Angela R Filous; Bradley T Lang; Amanda Tran; Jerry Silver
Journal: Exp Neurol Date: 2014-01-11 Impact factor: 5.330

6. Reactive astrocytes protect tissue and preserve function after spinal cord injury.

Authors: Jill R Faulkner; Julia E Herrmann; Michael J Woo; Keith E Tansey; Ngan B Doan; Michael V Sofroniew
Journal: J Neurosci Date: 2004-03-03 Impact factor: 6.167

7. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model.

Authors: Samuel E Nutt; Eun-Ah Chang; Steven T Suhr; Laura O Schlosser; Sarah E Mondello; Chet T Moritz; Jose B Cibelli; Philip J Horner
Journal: Exp Neurol Date: 2013-07-25 Impact factor: 5.330

8. Characterization of hyaluronan-methylcellulose hydrogels for cell delivery to the injured spinal cord.

Authors: Matthew J Caicco; Tasneem Zahir; Andrea J Mothe; Brian G Ballios; Anthony J Kihm; Charles H Tator; Molly S Shoichet
Journal: J Biomed Mater Res A Date: 2012-11-05 Impact factor: 4.396

9. Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling.

Authors: Barry W Festoff; Syed Ameenuddin; Karen Santacruz; John Morser; Zhiming Suo; Paul M Arnold; Kristie E Stricker; Bruce A Citron
Journal: J Neurotrauma Date: 2004-07 Impact factor: 5.269