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Literature DB >> 24424280

Functional regeneration beyond the glial scar.

Jared M Cregg¹, Marc A DePaul¹, Angela R Filous¹, Bradley T Lang¹, Amanda Tran¹, Jerry Silver².

Abstract

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology.

Entities: Chemical Disease Gene Species

Keywords: Axon growth cone; Chondroitin sulfate proteoglycans; Glial scar; Hypertrophy; Regeneration; Spinal cord injury

Mesh：

Year: 2014 PMID： 24424280 PMCID： PMC3951813 DOI： 10.1016/j.expneurol.2013.12.024

Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330

134 in total

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Authors: Ali Ertürk; Christoph P Mauch; Farida Hellal; Friedrich Förstner; Tara Keck; Klaus Becker; Nina Jährling; Heinz Steffens; Melanie Richter; Mark Hübener; Edgar Kramer; Frank Kirchhoff; Hans Ulrich Dodt; Frank Bradke
Journal: Nat Med Date: 2011-12-25 Impact factor: 53.440

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Authors: Y Li; G Raisman
Journal: Exp Neurol Date: 1995-07 Impact factor: 5.330

3. Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration.

Authors: Christopher Haas; Birgit Neuhuber; Takaya Yamagami; Mahendra Rao; Itzhak Fischer
Journal: Exp Neurol Date: 2011-11-10 Impact factor: 5.330

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Journal: J Neurosci Res Date: 1995-07-01 Impact factor: 4.164

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Authors: Joshua M Brown; Jiang Xia; BinQuan Zhuang; Kin-Sang Cho; Claude J Rogers; Cristal I Gama; Manish Rawat; Sarah E Tully; Noriko Uetani; Daniel E Mason; Michel L Tremblay; Eric C Peters; Osami Habuchi; Dong F Chen; Linda C Hsieh-Wilson
Journal: Proc Natl Acad Sci U S A Date: 2012-03-12 Impact factor: 11.205

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Authors: X M Xu; V Guénard; N Kleitman; P Aebischer; M B Bunge
Journal: Exp Neurol Date: 1995-08 Impact factor: 5.330

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Journal: Exp Neurol Date: 1995-02 Impact factor: 5.330

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Authors: K E Dow; D W Ethell; J D Steeves; R J Riopelle
Journal: Exp Neurol Date: 1994-08 Impact factor: 5.330

Review 9. Proteins of the intermediate filament cytoskeleton as markers for astrocytes and human astrocytomas.

Authors: H Y Yang; N Lieska; D Shao; V Kriho; G D Pappas
Journal: Mol Chem Neuropathol Date: 1994 Feb-Apr

10. Chronic in vivo imaging in the mouse spinal cord using an implanted chamber.

Authors: Matthew J Farrar; Ida M Bernstein; Donald H Schlafer; Thomas A Cleland; Joseph R Fetcho; Chris B Schaffer
Journal: Nat Methods Date: 2012-01-22 Impact factor: 28.547

223 in total

Review 1. Biomaterial Approaches to Modulate Reactive Astroglial Response.

Authors: Jonathan M Zuidema; Ryan J Gilbert; Manoj K Gottipati
Journal: Cells Tissues Organs Date: 2018-12-05 Impact factor: 2.481

2. Dynamic membrane depolarization is an early regulator of ependymoglial cell response to spinal cord injury in axolotl.

Authors: Keith Sabin; Tiago Santos-Ferreira; Jaclyn Essig; Sarah Rudasill; Karen Echeverri
Journal: Dev Biol Date: 2015-10-20 Impact factor: 3.582

Review 3. Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.

Authors: Erna A van Niekerk; Mark H Tuszynski; Paul Lu; Jennifer N Dulin
Journal: Mol Cell Proteomics Date: 2015-12-22 Impact factor: 5.911

Review 4. Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury.

Authors: Arsalan Alizadeh; Soheila Karimi-Abdolrezaee
Journal: J Physiol Date: 2016-03-29 Impact factor: 5.182

5. Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

Authors: Gregory M Miller; Linda C Hsieh-Wilson
Journal: Exp Neurol Date: 2015-08-24 Impact factor: 5.330

Review 6. Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury.

Authors: Yunxiang Zhou; Anwen Shao; Yihan Yao; Sheng Tu; Yongchuan Deng; Jianmin Zhang
Journal: Cell Commun Signal Date: 2020-04-15 Impact factor: 5.712

7. Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.

Authors: Jörg Ruschel; Farida Hellal; Kevin C Flynn; Sebastian Dupraz; David A Elliott; Andrea Tedeschi; Margaret Bates; Christopher Sliwinski; Gary Brook; Kristina Dobrindt; Michael Peitz; Oliver Brüstle; Michael D Norenberg; Armin Blesch; Norbert Weidner; Mary Bartlett Bunge; John L Bixby; Frank Bradke
Journal: Science Date: 2015-03-12 Impact factor: 47.728