| Literature DB >> 25586992 |
Maria Kabisch1, Justo Lorenzo Bermejo2, Thomas Dünnebier1, Shibo Ying1, Kyriaki Michailidou3, Manjeet K Bolla3, Qin Wang3, Joe Dennis3, Mitul Shah4, Barbara J Perkins4, Kamila Czene5, Hatef Darabi5, Mikael Eriksson5, Stig E Bojesen6, Børge G Nordestgaard6, Sune F Nielsen6, Henrik Flyger7, Diether Lambrechts8, Patrick Neven9, Stephanie Peeters9, Caroline Weltens9, Fergus J Couch10, Janet E Olson11, Xianshu Wang10, Kristen Purrington12, Jenny Chang-Claude13, Anja Rudolph13, Petra Seibold13, Dieter Flesch-Janys14, Julian Peto15, Isabel dos-Santos-Silva15, Nichola Johnson16, Olivia Fletcher16, Heli Nevanlinna17, Taru A Muranen17, Kristiina Aittomäki18, Carl Blomqvist19, Marjanka K Schmidt20, Annegien Broeks20, Sten Cornelissen20, Frans B L Hogervorst20, Jingmei Li21, Judith S Brand5, Keith Humphreys5, Pascal Guénel22, Thérèse Truong22, Florence Menegaux22, Marie Sanchez22, Barbara Burwinkel23, Frederik Marmé24, Rongxi Yang23, Peter Bugert25, Anna González-Neira26, Javier Benitez, M Pilar Zamora27, Jose I Arias Perez28, Angela Cox29, Simon S Cross30, Malcolm W R Reed29, Irene L Andrulis31, Julia A Knight32, Gord Glendon33, Sandrine Tchatchou34, Elinor J Sawyer35, Ian Tomlinson36, Michael J Kerin37, Nicola Miller37, Christopher A Haiman38, Fredrick Schumacher38, Brian E Henderson38, Loic Le Marchand39, Annika Lindblom40, Sara Margolin41, Maartje J Hooning42, Antoinette Hollestelle42, Mieke Kriege42, Linetta B Koppert43, John L Hopper44, Melissa C Southey45, Helen Tsimiklis45, Carmel Apicella44, Seth Slettedahl11, Amanda E Toland46, Celine Vachon11, Drakoulis Yannoukakos47, Graham G Giles48, Roger L Milne48, Catriona McLean49, Peter A Fasching, Matthias Ruebner50, Arif B Ekici51, Matthias W Beckmann50, Hermann Brenner52, Aida K Dieffenbach52, Volker Arndt53, Christa Stegmaier54, Alan Ashworth16, Nicholas Orr16, Minouk J Schoemaker55, Anthony Swerdlow56, Montserrat García-Closas57, Jonine Figueroa58, Stephen J Chanock58, Jolanta Lissowska59, Mark S Goldberg60, France Labrèche61, Martine Dumont62, Robert Winqvist63, Katri Pylkäs63, Arja Jukkola-Vuorinen64, Mervi Grip65, Hiltrud Brauch, Thomas Brüning66, Yon-Dschun Ko67, Paolo Radice68, Paolo Peterlongo69, Giulietta Scuvera70, Stefano Fortuzzi71, Natalia Bogdanova72, Thilo Dörk73, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Peter Devilee74, Robert A E M Tollenaar75, Caroline Seynaeve42, Christi J Van Asperen76, Anna Jakubowska77, Jan Lubinski77, Katarzyna Jaworska-Bieniek77, Katarzyna Durda77, Wei Zheng78, Martha J Shrubsole78, Qiuyin Cai78, Diana Torres79, Hoda Anton-Culver80, Vessela Kristensen, François Bacot81, Daniel C Tessier81, Daniel Vincent81, Craig Luccarini4, Caroline Baynes4, Shahana Ahmed4, Mel Maranian4, Jacques Simard62, Georgia Chenevix-Trench82, Per Hall5, Paul D P Pharoah28, Alison M Dunning4, Douglas F Easton28, Ute Hamann83.
Abstract
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the relationship between single nucleotide polymorphisms (SNPs) in genes encoding key CPC components and breast cancer risk. Fifteen SNPs in four CPC genes (INCENP, AURKB, BIRC5 and CDCA8) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium. Possible associations were investigated in fixed-effects meta-analyses. The synonymous SNP rs1675126 in exon 7 of INCENP was associated with overall breast cancer risk [per A allele odds ratio (OR) 0.95, 95% confidence interval (CI) 0.92-0.98, P = 0.007] and particularly with estrogen receptor (ER)-negative breast tumors (per A allele OR 0.89, 95% CI 0.83-0.95, P = 0.0005). SNPs not directly genotyped were imputed based on 1000 Genomes. The SNPs rs1047739 in the 3' untranslated region and rs144045115 downstream of INCENP showed the strongest association signals for overall (per T allele OR 1.03, 95% CI 1.00-1.06, P = 0.0009) and ER-negative breast cancer risk (per A allele OR 1.06, 95% CI 1.02-1.10, P = 0.0002). Two genotyped SNPs in BIRC5 were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04-1.21, P = 0.002). The data suggest that INCENP in the CPC pathway contributes to ER-negative breast cancer susceptibility in the European population. In spite of a modest contribution of CPC-inherited variants to the total burden of sporadic and familial breast cancer, their potential as novel targets for breast cancer treatment should be further investigated.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25586992 PMCID： PMC4335262 DOI： 10.1093/carcin/bgu326
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944