Literature DB >> 25586520

Statin treatment for older adults: the impact of the 2013 ACC/AHA cholesterol guidelines.

Yitzchak Weinberger1, Benjamin H Han.   

Abstract

The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults with cardiovascular disease for secondary prevention and with high cardiovascular risk for primary prevention, the evidence is lacking for older adults without major cardiovascular risk aside from age. The unclear evidence base for older adults must be considered along with the potential harms of statin therapy when incorporating the 2013 ACC/AHA practice guidelines for considering statin treatment, particularly for primary prevention for older adults.

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Year:  2015        PMID: 25586520     DOI: 10.1007/s40266-014-0238-5

Source DB:  PubMed          Journal:  Drugs Aging        ISSN: 1170-229X            Impact factor:   3.923


  37 in total

1.  ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins.

Authors:  Richard C Pasternak; Sidney C Smith; C Noel Bairey-Merz; Scott M Grundy; James I Cleeman; Claude Lenfant
Journal:  Circulation       Date:  2002-08-20       Impact factor: 29.690

Review 2.  Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials.

Authors:  Donna M Zulman; Jeremy B Sussman; Xisui Chen; Christine T Cigolle; Caroline S Blaum; Rodney A Hayward
Journal:  J Gen Intern Med       Date:  2011-02-01       Impact factor: 5.128

3.  Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial.

Authors:  Beatrice A Golomb; Marcella A Evans; Joel E Dimsdale; Halbert L White
Journal:  Arch Intern Med       Date:  2012-08-13

4.  Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.

Authors:  David Preiss; Sreenivasa Rao Kondapally Seshasai; Paul Welsh; Sabina A Murphy; Jennifer E Ho; David D Waters; David A DeMicco; Philip Barter; Christopher P Cannon; Marc S Sabatine; Eugene Braunwald; John J P Kastelein; James A de Lemos; Michael A Blazing; Terje R Pedersen; Matti J Tikkanen; Naveed Sattar; Kausik K Ray
Journal:  JAMA       Date:  2011-06-22       Impact factor: 56.272

5.  Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial.

Authors:  Robert J Glynn; Wolfgang Koenig; Børge G Nordestgaard; James Shepherd; Paul M Ridker
Journal:  Ann Intern Med       Date:  2010-04-20       Impact factor: 25.391

6.  The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.

Authors:  F M Sacks; M A Pfeffer; L A Moye; J L Rouleau; J D Rutherford; T G Cole; L Brown; J W Warnica; J M Arnold; C C Wun; B R Davis; E Braunwald
Journal:  N Engl J Med       Date:  1996-10-03       Impact factor: 91.245

7.  Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.

Authors:  David J Graham; Judy A Staffa; Deborah Shatin; Susan E Andrade; Stephanie D Schech; Lois La Grenade; Jerry H Gurwitz; K Arnold Chan; Michael J Goodman; Richard Platt
Journal:  JAMA       Date:  2004-11-22       Impact factor: 56.272

8.  Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.

Authors:  Helen M Colhoun; D John Betteridge; Paul N Durrington; Graham A Hitman; H Andrew W Neil; Shona J Livingstone; Margaret J Thomason; Michael I Mackness; Valentine Charlton-Menys; John H Fuller
Journal:  Lancet       Date:  2004 Aug 21-27       Impact factor: 79.321

9.  Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database.

Authors:  Julia Hippisley-Cox; Carol Coupland
Journal:  BMJ       Date:  2010-05-20

10.  Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.

Authors:  J R Downs; M Clearfield; S Weis; E Whitney; D R Shapiro; P A Beere; A Langendorfer; E A Stein; W Kruyer; A M Gotto
Journal:  JAMA       Date:  1998-05-27       Impact factor: 56.272

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  3 in total

1.  Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial.

Authors:  Benjamin H Han; David Sutin; Jeff D Williamson; Barry R Davis; Linda B Piller; Hannah Pervin; Sara L Pressel; Caroline S Blaum
Journal:  JAMA Intern Med       Date:  2017-07-01       Impact factor: 21.873

2.  Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018.

Authors:  Catherine A Panozzo; Lesley H Curtis; James Marshall; Lawrence Fine; Barbara L Wells; Jeffrey S Brown; Kevin Haynes; Pamala A Pawloski; Adrian F Hernandez; Sarah Malek; Beth Syat; Richard Platt
Journal:  PLoS One       Date:  2019-12-05       Impact factor: 3.240

3.  Predicting Risk of Atherosclerotic Cardiovascular Disease Using Pooled Cohort Equations in Older Adults With Frailty, Multimorbidity, and Competing Risks.

Authors:  Quoc Dinh Nguyen; Michelle C Odden; Carmen A Peralta; Dae Hyun Kim
Journal:  J Am Heart Assoc       Date:  2020-09-02       Impact factor: 5.501

  3 in total

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