Vijaykumar M Pujari1, Shankargouda Ireddy2, Inderraj Itagi3, Siddesh Kumar H4. 1. Associate Professor Department of Biochemistry, RIMS , Raichur, Karnataka, India . 2. Associate Professor, Deparment of Skin and V D, RIMS , Raichur, Karnataka, India . 3. Associate Professor Department of Pathology, RIMS , Raichur, Karnataka, India . 4. Associate Professor Department of Ophthalmology, RIMS , Raichur, Karnataka, India .
Abstract
BACKGROUND: Psoriasis is a common skin disease which is characterized by increased epidermal proliferation and dermal inflammation affecting 0.1-3% of general population. Most of the psoriasis patients are young or middle aged adults, although no age exempted. The oxidative stress develops due to imbalance in oxidants and antioxidants, which was proposed to have role in psoriasis. AIMS AND OBJECTIVES: The presented research work was planned to evaluate oxidative stress by measuring serum malondialdehyde (MDA) as oxidant and serum vitamin E, erythrocyte catalase (CAT) activity as antioxidants in psoriasis patients. MATERIALS AND METHODS: Total 90 clinically diagnosed psoriasis patients of age group of 20 to 60 years and without any drug therapy for preceding two months and 90 matched healthy controls were included in the presented study. The severity of psoriasis was determined by PASI score. The fasting blood sample collected and accessed for serum MDA, serum vitamin E and erythrocyte catalase activity. RESULTS: The study results were compiled and statistical analysis was done using students t-test. Our results showed significantly increased levels of serum MDA (p<0.001) and significantly decreased serum vitamin E (p<0.001) as well as erythrocyte catalase activity (p<0.001) in psoriasis patients as compared to controls. CONCLUSION: The presented study concluded the oxidative stress in psoriasis, indicated by increased serum MDA and decreased Vitamin E, erythrocyte catalase activity. Our study also supports the possibility of involvement of oxidative stress in pathogenesis of psoriasis.
BACKGROUND:Psoriasis is a common skin disease which is characterized by increased epidermal proliferation and dermal inflammation affecting 0.1-3% of general population. Most of the psoriasispatients are young or middle aged adults, although no age exempted. The oxidative stress develops due to imbalance in oxidants and antioxidants, which was proposed to have role in psoriasis. AIMS AND OBJECTIVES: The presented research work was planned to evaluate oxidative stress by measuring serum malondialdehyde (MDA) as oxidant and serum vitamin E, erythrocyte catalase (CAT) activity as antioxidants in psoriasispatients. MATERIALS AND METHODS: Total 90 clinically diagnosed psoriasispatients of age group of 20 to 60 years and without any drug therapy for preceding two months and 90 matched healthy controls were included in the presented study. The severity of psoriasis was determined by PASI score. The fasting blood sample collected and accessed for serum MDA, serum vitamin E and erythrocyte catalase activity. RESULTS: The study results were compiled and statistical analysis was done using students t-test. Our results showed significantly increased levels of serum MDA (p<0.001) and significantly decreased serum vitamin E (p<0.001) as well as erythrocyte catalase activity (p<0.001) in psoriasispatients as compared to controls. CONCLUSION: The presented study concluded the oxidative stress in psoriasis, indicated by increased serum MDA and decreased Vitamin E, erythrocyte catalase activity. Our study also supports the possibility of involvement of oxidative stress in pathogenesis of psoriasis.
Entities:
Keywords:
Catalase; MDA; Oxidative stress; Psoriasis; Vitamin E
Authors: A D Ormerod; R Weller; P Copeland; N Benjamin; S H Ralston; P Grabowksi; R Herriot Journal: Arch Dermatol Res Date: 1998 Jan-Feb Impact factor: 3.017
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