Literature DB >> 2558406

Evaluation of zinc complexes on the replication of rhinovirus 2 in vitro.

V J Merluzzi1, D Cipriano, D McNeil, V Fuchs, C Supeau, A S Rosenthal, J W Skiles.   

Abstract

The effect of zinc salts and complexes were evaluated on the replication of rhinovirus 2 in vitro. Zinc chloride inhibited the replication of rhinovirus 2 at concentrations between 3 and 12 micrograms/ml. Influenza virus was not affected. A number of zinc complexes were tested and compared to zinc chloride. The results indicated that the activity and toxicity of all zinc complexes in the rhinovirus cytopathogenic effect (CPE) assay were directly related to the amount of unbound zinc available.

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Year:  1989        PMID： 2558406

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  6 in total

1.  Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection.

Authors:  Nigel Bourne; Rachael Stegall; Raquel Montano; Michael Meador; Lawrence R Stanberry; Gregg N Milligan
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

2.  Additive Effects of Zinc Chloride on the Suppression of Hepatitis A Virus Replication by Interferon in Human Hepatoma Huh7 Cells.

Authors:  Tatsuo Kanda; Reina Sasaki; Ryota Masuzaki; Hiroshi Takahashi; Mariko Fujisawa; Naoki Matsumoto; Hiroaki Okamoto; Mitsuhiko Moriyama
Journal:  In Vivo       Date:  2020 Nov-Dec       Impact factor: 2.155

3.  Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV.

Authors:  John T-A Hsu; Chih-Jung Kuo; Hsing-Pang Hsieh; Yeau-Ching Wang; Kuo-Kuei Huang; Coney P-C Lin; Ping-Fang Huang; Xin Chen; Po-Huang Liang
Journal:  FEBS Lett       Date:  2004-09-10       Impact factor: 4.124

Review 4.  Efficacy of zinc against common cold viruses: an overview.

Authors:  Darrell Hulisz
Journal:  J Am Pharm Assoc (2003)       Date:  2004 Sep-Oct

5.  Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells.

Authors:  Meenakshi Kar; Naseem Ahmed Khan; Aleksha Panwar; Sachendra S Bais; Soumen Basak; Renu Goel; Shailaja Sopory; Guruprasad R Medigeshi
Journal:  Front Immunol       Date:  2019-10-01       Impact factor: 7.561

Review 6.  Zinc lozenges as cure for the common cold--a review and hypothesis.

Authors:  George A Eby
Journal:  Med Hypotheses       Date:  2009-11-10       Impact factor: 1.538
  6 in total

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