Literature DB >> 25582616

Altered mTORC1 signaling in multipotent stem cells from nearly 25% of patients with nonsyndromic autism spectrum disorders.

A M Suzuki1, K Griesi-Oliveira2, C de Oliveira Freitas Machado3, E Vadasz4, E C Zachi1, M R Passos-Bueno1, A L Sertie3.   

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Year:  2015        PMID： 25582616     DOI： 10.1038/mp.2014.175

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN： 1359-4184            Impact factor:   15.992


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  9 in total

1.  Stem cells as a good tool to investigate dysregulated biological systems in autism spectrum disorders.

Authors:  Karina Griesi-Oliveira; Daniele Yumi Sunaga; Lucas Alvizi; Estevão Vadasz; Maria Rita Passos-Bueno
Journal:  Autism Res       Date:  2013-06-25       Impact factor: 5.216

2.  Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome.

Authors:  C A Hoeffer; E Sanchez; R J Hagerman; Y Mu; D V Nguyen; H Wong; A M Whelan; R S Zukin; E Klann; F Tassone
Journal:  Genes Brain Behav       Date:  2012-02-15       Impact factor: 3.449

3.  Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR.

Authors:  A Oguro-Ando; C Rosensweig; E Herman; Y Nishimura; D Werling; B R Bill; J M Berg; F Gao; G Coppola; B S Abrahams; D H Geschwind
Journal:  Mol Psychiatry       Date:  2014-10-14       Impact factor: 15.992

Review 4.  Activity-dependent neuronal signalling and autism spectrum disorder.

Authors:  Daniel H Ebert; Michael E Greenberg
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962

5.  The autistic neuron: troubled translation?

Authors:  Raymond J Kelleher; Mark F Bear
Journal:  Cell       Date:  2008-10-31       Impact factor: 41.582

6.  Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.

Authors:  Jing Zhou; Jacqueline Blundell; Shiori Ogawa; Chang-Hyuk Kwon; Wei Zhang; Christopher Sinton; Craig M Powell; Luis F Parada
Journal:  J Neurosci       Date:  2009-02-11       Impact factor: 6.167

7.  Autism-related deficits via dysregulated eIF4E-dependent translational control.

Authors:  Christos G Gkogkas; Arkady Khoutorsky; Israeli Ran; Emmanouil Rampakakis; Tatiana Nevarko; Daniel B Weatherill; Cristina Vasuta; Stephanie Yee; Morgan Truitt; Paul Dallaire; François Major; Paul Lasko; Davide Ruggero; Karim Nader; Jean-Claude Lacaille; Nahum Sonenberg
Journal:  Nature       Date:  2012-11-21       Impact factor: 49.962

8.  A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival.

Authors:  Lynsey Meikle; Delia M Talos; Hiroaki Onda; Kristen Pollizzi; Alexander Rotenberg; Mustafa Sahin; Frances E Jensen; David J Kwiatkowski
Journal:  J Neurosci       Date:  2007-05-23       Impact factor: 6.167

9.  Mutations causing syndromic autism define an axis of synaptic pathophysiology.

Authors:  Benjamin D Auerbach; Emily K Osterweil; Mark F Bear
Journal:  Nature       Date:  2011-11-23       Impact factor: 49.962
  9 in total
  7 in total

1.  Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism.

Authors:  Camila Oliveira Freitas Machado; Karina Griesi-Oliveira; Carla Rosenberg; Fernando Kok; Stephanie Martins; Maria Rita Passos-Bueno; Andrea Laurato Sertie
Journal:  Eur J Hum Genet       Date:  2015-04-22       Impact factor: 4.246

Review 2.  Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder?

Authors:  Juliana Magdalon; Sandra M Sánchez-Sánchez; Karina Griesi-Oliveira; Andréa L Sertié
Journal:  Int J Mol Sci       Date:  2017-03-18       Impact factor: 5.923

Review 3.  Autophagy deficiency in neurodevelopmental disorders.

Authors:  Zhiqiang Deng; Xiaoting Zhou; Jia-Hong Lu; Zhenyu Yue
Journal:  Cell Biosci       Date:  2021-12-17       Impact factor: 7.133

4.  The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder.

Authors:  Cristan A Farmer; Audrey E Thurm; Bianca Honnekeri; Paul Kim; Susan E Swedo; Joan C Han
Journal:  Sci Rep       Date:  2021-09-13       Impact factor: 4.379

Review 5.  Genomics of autism spectrum disorder: approach to therapy.

Authors:  Fatma Ayhan; Genevieve Konopka
Journal:  F1000Res       Date:  2018-05-22

Review 6.  Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells.

Authors:  Louisa Hoi-Ying Lo; Kwok-On Lai
Journal:  Mol Autism       Date:  2020-05-27       Impact factor: 7.509

7.  Actin cytoskeleton dynamics in stem cells from autistic individuals.

Authors:  Karina Griesi-Oliveira; Angela May Suzuki; Aline Yasuda Alves; Ana Carolina Cintra Nunes Mafra; Guilherme Lopes Yamamoto; Suzana Ezquina; Yuli Thamires Magalhães; Fabio Luis Forti; Andrea Laurato Sertie; Elaine Cristina Zachi; Estevão Vadasz; Maria Rita Passos-Bueno
Journal:  Sci Rep       Date:  2018-07-24       Impact factor: 4.379
  7 in total

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