Ron Noah Alkalay1, David Vader2, David Hackney3. 1. Center for Advanced Orthopedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA. Electronic address: ralkalay@bidmc.harvard.edu. 2. Center for Advanced Orthopedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA. 3. Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.
Abstract
BACKGROUND: In the elderly, 30%-50% of patients report a fall event to precede the onset of vertebral fractures. The dynamic characteristics of the spine determine the peak forces on the vertebrae in a fall. However, we know little about the effect of intervertebral disk degeneration on the failure of human spines under the high loading rates associated with such falls. We hypothesized that MR estimates of disk hydration and viscoelastic properties will provide better estimates of failure strength than bone density alone. METHODS: Seventeen L1-L3 human spine segments were imaged (magnetic resonance imaging, dual-energy X-ray absorptiometry), their dynamic responses quantified using pendulum based impact, and the spines tested to failure under high rate loading simulating a fall event. The spines' stiffness and damping constants were computed (Kelvin-Voigt model) with disk hydration and geometry assessed from T2 and proton density images. FINDINGS: Under impact, the spines exhibited a second-order underdamped response with stiffness and damping ranging (17.9-754.5) kN/m and (133.6-905.3) Ns/m respectively. Damping, but not stiffness, was negatively correlated with higher ultimate strength (P<0.05). Higher bone mineral density and MR-estimated disk hydration correlated with higher ultimate strength (P<0.01 for both). No such correlations were observed for the T2 values. Adding disk hydration yielded a 20% increase in the model's association with failure load compared to bone density alone (MANOVA, P<0.001). INTERPRETATION: The strong correlation between disk viscoelastic properties and MR-estimated hydration with the spine segments' ultimate strength clearly demonstrates the need to include disk degeneration as part of fracture risk assessment in the elderly spine.
BACKGROUND: In the elderly, 30%-50% of patients report a fall event to precede the onset of vertebral fractures. The dynamic characteristics of the spine determine the peak forces on the vertebrae in a fall. However, we know little about the effect of intervertebral disk degeneration on the failure of human spines under the high loading rates associated with such falls. We hypothesized that MR estimates of disk hydration and viscoelastic properties will provide better estimates of failure strength than bone density alone. METHODS: Seventeen L1-L3 human spine segments were imaged (magnetic resonance imaging, dual-energy X-ray absorptiometry), their dynamic responses quantified using pendulum based impact, and the spines tested to failure under high rate loading simulating a fall event. The spines' stiffness and damping constants were computed (Kelvin-Voigt model) with disk hydration and geometry assessed from T2 and proton density images. FINDINGS: Under impact, the spines exhibited a second-order underdamped response with stiffness and damping ranging (17.9-754.5) kN/m and (133.6-905.3) Ns/m respectively. Damping, but not stiffness, was negatively correlated with higher ultimate strength (P<0.05). Higher bone mineral density and MR-estimated disk hydration correlated with higher ultimate strength (P<0.01 for both). No such correlations were observed for the T2 values. Adding disk hydration yielded a 20% increase in the model's association with failure load compared to bone density alone (MANOVA, P<0.001). INTERPRETATION: The strong correlation between disk viscoelastic properties and MR-estimated hydration with the spine segments' ultimate strength clearly demonstrates the need to include disk degeneration as part of fracture risk assessment in the elderly spine.