Jose C Vanegas1, Myriam C Afeiche2, Audrey J Gaskins3, Lidia Mínguez-Alarcón2, Paige L Williams4, Diane L Wright5, Thomas L Toth5, Russ Hauser6, Jorge E Chavarro7. 1. School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia. 2. Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts. 3. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. 4. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts. 5. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 6. Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 7. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: jchavarr@hsph.harvard.edu.
Abstract
OBJECTIVE: To study the relation of dietary phytoestrogens intake and clinical outcomes of women undergoing infertility treatment with the use of assisted reproductive technology (ART). DESIGN: Prospective cohort study. SETTING: Fertility center. PATIENT(S): A total of 315 women who collectively underwent 520 ART cycles from 2007 to 2013. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation, clinical pregnancy, and live birth rates per initiated cycle. RESULT(S): Soy isoflavones intake was positively related to live birth rates in ART. Compared with women who did not consume soy isoflavones, the multivariable-adjusted odds ratios of live birth (95% confidence interval) for women in increasing categories of soy isoflavones intake were 1.32 (0.76-2.27) for women consuming 0.54-2.63 mg/d, 1.87 (1.12-3.14) for women consuming 2.64-7.55 mg/d, and 1.77 (1.03-3.03) for women consuming 7.56-27.89 mg/d. CONCLUSION(S): Dietary soy intake was positively related to the probability of having a live birth during infertility treatment with ART.
OBJECTIVE: To study the relation of dietary phytoestrogens intake and clinical outcomes of women undergoing infertility treatment with the use of assisted reproductive technology (ART). DESIGN: Prospective cohort study. SETTING: Fertility center. PATIENT(S): A total of 315 women who collectively underwent 520 ART cycles from 2007 to 2013. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation, clinical pregnancy, and live birth rates per initiated cycle. RESULT(S): Soy isoflavones intake was positively related to live birth rates in ART. Compared with women who did not consume soy isoflavones, the multivariable-adjusted odds ratios of live birth (95% confidence interval) for women in increasing categories of soy isoflavones intake were 1.32 (0.76-2.27) for women consuming 0.54-2.63 mg/d, 1.87 (1.12-3.14) for women consuming 2.64-7.55 mg/d, and 1.77 (1.03-3.03) for women consuming 7.56-27.89 mg/d. CONCLUSION(S): Dietary soy intake was positively related to the probability of having a live birth during infertility treatment with ART.
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