William P Sexauer1, Anas Hadeh2, Pamela A Ohman-Strickland3, Robert L Zanni4, Laurie Varlotta5, Douglas Holsclaw6, Stanley Fiel7, Gavin R Graff8, Arthur Atlas9, Dorothy Bisberg10, Denis Hadjiliadis6, Suzanne H Michel11, Daria Mintz12, Rebanta Chakraborty13, Bridget Marra4, Paula Lomas7, Tara Ward14, Meagen Sassman15, Giovanna C Imbesi6, Diane M Kitch8, Allison M Mallowe16. 1. Pulmonary and Critical Care Division, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: william.sexauer@jefferson.edu. 2. Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Drexel University College of Medicine, Philadelphia, PA, USA; Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Florida, Weston, FL, USA. 3. Rutgers School of Public Health, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 4. Pulmonary Division, Department of Pediatrics, Monmouth Medical Center, Long Branch, NJ, USA. 5. Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA; Section of Pediatric Pulmonology, St. Christopher's Hospital for Children, Philadelphia, PA, USA. 6. Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7. Adult Cystic Fibrosis Center, Morristown Medical Center, Morristown, NJ, USA. 8. Pulmonary Division, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. 9. Pulmonary Division, Department of Pediatrics, Goryeb Children's Hospital, Morristown Medical Center, Morristown, NJ, USA. 10. Barnabas Health, West Orange, NJ, USA. 11. Pulmonary Division, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA. 12. Pulmonary Division, Department of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 13. Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. 14. Department of Medicine, Morristown Medical Center, Morristown, NJ, USA. 15. Cystic Fibrosis Center, St. Christopher's Hospital for Children, Philadelphia, PA, USA. 16. Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abstract
BACKGROUND: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. METHODS: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. RESULTS: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. CONCLUSIONS: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.
BACKGROUND:Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. METHODS: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. RESULTS: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. CONCLUSIONS: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.
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