Wei Xiao1, Weifeng Gong1, Qianyun Chen1, Xiaohu Ding1, Billy Chang1, Mingguang He2. 1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. 2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Centre for Eye Research Australia, University of Melbourne, Australia.
Abstract
PURPOSE: To elucidate the relationship between body composition and retinal vascular caliber (RVC) in children and adolescents. METHODS: Participants aged 7 to 19 years were recruited from the Guangzhou Twin Eye Study cohort. Retinal vascular caliber was measured cross-sectionally from retinal images using a computer-aided program. The data were expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Triceps skinfold thickness (TSFT) was measured using a skinfold caliper. Body composition was obtained through bioelectrical impedance analysis, providing fat mass (FM), fat mass index (FMI), fat-free mass (FFM), fat-free mass index (FFMI), body water mass (BWM), body water percentage (BWP), basal metabolic rate (BMR), and trunk fat percentage (TFP). RESULTS: A total of 731 participants were included. Among the younger children (7-11 years), there was no significant association between body composition and RVC (all P > 0.05). However, for the older children (12-19 years), increasing FM, FMI, TFP, TSFT, and BMI were associated with CRAE negatively (β = -0.20, -0.68, -0.18, -0.17, and -0.48, respectively, all P < 0.05) and with CRVE positively (β = 0.47, 1.26, 0.34, 0.37, and 0.78, respectively, all P < 0.05), after adjusting for age, sex, axial length, mean arterial blood pressure, and the fellow vascular diameter. In contrast, increase in BWP was associated with larger CRAE (β = 0.33, P = 0.001) and smaller CRVE (β = -0.64, P < 0.001). Similar associations also were observed in the analyses when the body composition parameters were divided into quartiles (all P < 0.05). CONCLUSIONS: In adolescents, greater body fat deposition is related to narrower retinal arterioles and wider retinal venules, and higher body water proportion is associated with retinal arterioles widening and retinal venules narrowing. Even during childhood, body composition might have an association with systemic microvasculature. Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To elucidate the relationship between body composition and retinal vascular caliber (RVC) in children and adolescents. METHODS:Participants aged 7 to 19 years were recruited from the Guangzhou Twin Eye Study cohort. Retinal vascular caliber was measured cross-sectionally from retinal images using a computer-aided program. The data were expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Triceps skinfold thickness (TSFT) was measured using a skinfold caliper. Body composition was obtained through bioelectrical impedance analysis, providing fat mass (FM), fat mass index (FMI), fat-free mass (FFM), fat-free mass index (FFMI), body water mass (BWM), body water percentage (BWP), basal metabolic rate (BMR), and trunk fat percentage (TFP). RESULTS: A total of 731 participants were included. Among the younger children (7-11 years), there was no significant association between body composition and RVC (all P > 0.05). However, for the older children (12-19 years), increasing FM, FMI, TFP, TSFT, and BMI were associated with CRAE negatively (β = -0.20, -0.68, -0.18, -0.17, and -0.48, respectively, all P < 0.05) and with CRVE positively (β = 0.47, 1.26, 0.34, 0.37, and 0.78, respectively, all P < 0.05), after adjusting for age, sex, axial length, mean arterial blood pressure, and the fellow vascular diameter. In contrast, increase in BWP was associated with larger CRAE (β = 0.33, P = 0.001) and smaller CRVE (β = -0.64, P < 0.001). Similar associations also were observed in the analyses when the body composition parameters were divided into quartiles (all P < 0.05). CONCLUSIONS: In adolescents, greater body fat deposition is related to narrower retinal arterioles and wider retinal venules, and higher body water proportion is associated with retinal arterioles widening and retinal venules narrowing. Even during childhood, body composition might have an association with systemic microvasculature. Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
Entities:
Keywords:
body composition; children; microvasculature; obesity
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