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Literature DB >> 25572815

SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma.

Dong Wang¹, Sheng Han, Xing Wang, Rui Peng, Xiangcheng Li.

Abstract

The transcription factor sex determining region Y-box protein 5 (SOX5) plays important roles in various types of cancers. However, the expression and function of SOX5 in hepatocellular carcinoma (HCC) have not been elucidated. Here, we found that SOX5 is significantly up-regulated in HCC tissues and cell lines. Gain- and loss-of-function studies demonstrated that SOX5 promoted HCC cell migration and invasion. In addition, we revealed that SOX5 is linked to epithelial-mesenchymal transition (EMT) by regulation of Twist1. Our results indicate for the first time that SOX5 is a novel regulator of EMT in HCC and may be a potential therapeutic target for HCC metastasis.

Entities: Disease Gene

Mesh：

Substances：

Year: 2015 PMID： 25572815 DOI： 10.1007/s12032-014-0461-2

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

34 in total

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Journal: Cell Signal Date: 2013-02-15 Impact factor: 4.315

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Journal: Pathobiology Date: 2012-04-04 Impact factor: 4.342

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Authors: Alexander Gheldof; Geert Berx
Journal: Prog Mol Biol Transl Sci Date: 2013 Impact factor: 3.622

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Authors: Raghu Kalluri; Robert A Weinberg
Journal: J Clin Invest Date: 2009-06 Impact factor: 14.808

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23 in total

1. SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells.

Authors: Hongbo Zou; Shuang Wang; Songtao Wang; Hong Wu; Jing Yu; Qian Chen; Wei Cui; Ye Yuan; Xianmei Wen; Jian He; Lin Chen; Ruilian Yu; Ming Zhang; Haitao Lan; Guoxiang Jin; Xia Zhang; Xiuwu Bian; Chuan Xu
Journal: Am J Cancer Res Date: 2018-05-01 Impact factor: 6.166

2. SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7.

Authors: Jie Chen; Yunzhi Dang; Weibo Feng; Chenyang Qiao; Danfei Liu; Tongyue Zhang; Yijun Wang; Dean Tian; Daiming Fan; Yongzhan Nie; Kaichun Wu; Limin Xia
Journal: Oncogene Date: 2020-07-02 Impact factor: 9.867

3. LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.

Authors: Ri Chen; Chunfan Zhang; Yuanda Cheng; Shaoqiang Wang; Hang Lin; Heng Zhang
Journal: Lab Invest Date: 2021-04-06 Impact factor: 5.662

4. CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.

Authors: Qingyu Liu; Yanning Cai; Haiquan Xiong; Yiyun Deng; Xianhua Dai
Journal: Database (Oxford) Date: 2019-01-01 Impact factor: 3.451

Review 5. Emerging Role of SOX Proteins in Breast Cancer Development and Maintenance.

Authors: Gaurav A Mehta; Pooja Khanna; Michael L Gatza
Journal: J Mammary Gland Biol Neoplasia Date: 2019-05-09 Impact factor: 2.673

Review 6. The role of TWIST1 in epithelial-mesenchymal transition and cancers.

Authors: Qing-Qing Zhu; Chenhui Ma; Qian Wang; Yong Song; Tangfeng Lv
Journal: Tumour Biol Date: 2015-11-24

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Authors: Xiaoke Feng; Yumeng Shi; Lingxiao Xu; Qiuyue Peng; Fang Wang; Xiaoxi Wang; Wei Sun; Yan Lu; Betty P Tsao; Miaojia Zhang; Wenfeng Tan
Journal: Sci Rep Date: 2016-08-23 Impact factor: 4.379

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Authors: Hanzhi Ding; Hong Quan; Weiguo Yan; Jing Han
Journal: Biosci Rep Date: 2016-08-31 Impact factor: 3.840

9. Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression.

Authors: Jieping Hu; Jing Tian; Shimiao Zhu; Libin Sun; Jianpeng Yu; Hao Tian; Qian Dong; Qiang Luo; Ning Jiang; Yuanjie Niu; Zhiqun Shang
Journal: Br J Cancer Date: 2017-11-09 Impact factor: 7.640

10. Genome-Wide Methylation Patterns in Androgen-Independent Prostate Cancer Cells: A Comprehensive Analysis Combining MeDIP-Bisulfite, RNA, and microRNA Sequencing Data.

Authors: Yumin Wang; Tingting Qin; Wangqiang Hu; Binghua Chen; Meijie Dai; Gang Xu
Journal: Genes (Basel) Date: 2018-01-11 Impact factor: 4.096