Literature DB >> 2556107

The action of defined oxygen-centred free radicals on human low-density lipoprotein.

S Bedwell1, R T Dean, W Jessup.   

Abstract

The effects of defined oxygen-centred free radicals on human low-density lipoprotein (LDL) structure and receptor affinity are discussed in relation to the mechanisms of cell-mediated oxidative modification of LDL. Both hydroxyl (OH.) and hydroperoxyl (HO2.) radicals caused depletion of endogenous alpha-tocopherol and formation of hydroperoxides. Superoxide (O2-.) radicals produced only very limited oxidation, but could potentiate oxidation stimulated by the addition of Cu2+. All these radicals enhanced the net negative charge of intact LDL and induced fragmentation of apolipoprotein B-100 (apo B). OH. also caused cross-linking of apo B. Radical attack decreased the affinity of LDL for the fibroblast apo B/E receptor, but did not enhance its endocytosis by mouse macrophages.

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Year:  1989        PMID： 2556107      PMCID： PMC1133332          DOI： 10.1042/bj2620707

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.

Authors:  R J HAVEL; H A EDER; J H BRAGDON
Journal:  J Clin Invest       Date:  1955-09       Impact factor: 14.808

2.  Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

Authors:  K H Weisgraber; T L Innerarity; R W Mahley
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

3.  Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

Authors:  S K Basu; J L Goldstein; G W Anderson; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

4.  Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

Authors:  S Ohkuma; B Poole
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

5.  The modification of low density lipoproteins by macrophages by oxidation or proteolysis.

Authors:  S M Rankin; D S Leake
Journal:  Agents Actions Suppl       Date:  1988

6.  Oxygen-mediated heterogeneity of apo-low-density lipoprotein.

Authors:  J Schuh; G F Fairclough; R H Haschemeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

7.  A continuous-flow automated assay for iodometric estimation of hydroperoxides.

Authors:  S M Thomas; W Jessup; J M Gebicki; R T Dean
Journal:  Anal Biochem       Date:  1989-02-01       Impact factor: 3.365

8.  The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations.

Authors:  D W Bilheimer; S Eisenberg; R I Levy
Journal:  Biochim Biophys Acta       Date:  1972-02-21

9.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

10.  Hydroperoxide-mediated fragmentation of proteins.

Authors:  J V Hunt; J A Simpson; R T Dean
Journal:  Biochem J       Date:  1988-02-15       Impact factor: 3.857
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  14 in total

1.  Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein.

Authors:  M Yang; D S Leake; C A Rice-Evans
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857

Review 2.  Review of progress in sterol oxidations: 1987-1995.

Authors:  L L Smith
Journal:  Lipids       Date:  1996-05       Impact factor: 1.880

Review 3.  Biochemistry and pathology of radical-mediated protein oxidation.

Authors:  R T Dean; S Fu; R Stocker; M J Davies
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

4.  Resistance of lipoprotein(a) to lipid peroxidation induced by oxygenated free radicals produced by gamma radiolysis: a comparison with low-density lipoprotein.

Authors:  J L Beaudeux; M Gardes-Albert; J Delattre; A Legrand; F Rousselet; J Peynet
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

Review 5.  Superoxide dismutases: role in redox signaling, vascular function, and diseases.

Authors:  Tohru Fukai; Masuko Ushio-Fukai
Journal:  Antioxid Redox Signal       Date:  2011-06-06       Impact factor: 8.401

Review 6.  Free radicals: properties, sources, targets, and their implication in various diseases.

Authors:  Alugoju Phaniendra; Dinesh Babu Jestadi; Latha Periyasamy
Journal:  Indian J Clin Biochem       Date:  2014-07-15

7.  Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production.

Authors:  B Garner; R T Dean; W Jessup
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

8.  Effects of oxidative modification of cholesterol in isolated low density lipoproteins on cultured smooth muscle cells.

Authors:  K Z Liu; B Ramjiawan; M J Kutryk; G N Pierce
Journal:  Mol Cell Biochem       Date:  1991-11-13       Impact factor: 3.396

9.  Alpha-tocopherol consumption during low-density-lipoprotein oxidation.

Authors:  W Jessup; S M Rankin; C V De Whalley; J R Hoult; J Scott; D S Leake
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857

10.  Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu(2+)-induced oxidation.

Authors:  D F Meyer; M O Mayans; P H Groot; K E Suckling; K R Bruckdorfer; S J Perkins
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857
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