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Literature DB >> 25560385

Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.

Brian León¹, Gabriel Navarro, Bailey J Dickey, George Stepan, Angela Tsai, Gregg S Jones, Monica E Morales, Tiffany Barnes, Shekeba Ahmadyar, Manuel Tsiang, Romas Geleziunas, Tomas Cihlar, Nikos Pagratis, Yang Tian, Helen Yu, Roger G Linington.

Abstract

Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25560385 PMCID： PMC5755699 DOI： 10.1021/ol503349y

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

26 in total

1. Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway.

Authors: Bojan Bister; Daniel Bischoff; Markus Ströbele; Julia Riedlinger; Andreas Reicke; Falko Wolter; Alan T Bull; Hans Zähner; Hans-Peter Fiedler; Roderich D Süssmuth
Journal: Angew Chem Int Ed Engl Date: 2004-05-03 Impact factor: 15.336

2. Action of atrop-abyssomicin C as an inhibitor of 4-amino-4-deoxychorismate synthase PabB.

Authors: Simone Keller; Heiko S Schadt; Ingo Ortel; Roderich D Süssmuth
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

Review 3. The challenge of finding a cure for HIV infection.

Authors: Douglas D Richman; David M Margolis; Martin Delaney; Warner C Greene; Daria Hazuda; Roger J Pomerantz
Journal: Science Date: 2009-03-06 Impact factor: 47.728

Review 4. Cardiovascular risks of antiretroviral therapies.

Authors: Kristin Mondy; Pablo Tebas
Journal: Annu Rev Med Date: 2007 Impact factor: 13.739

5. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.

Authors: Ginger Lehrman; Ian B Hogue; Sarah Palmer; Cheryl Jennings; Celsa A Spina; Ann Wiegand; Alan L Landay; Robert W Coombs; Douglas D Richman; John W Mellors; John M Coffin; Ronald J Bosch; David M Margolis
Journal: Lancet Date: 2005 Aug 13-19 Impact factor: 79.321

6. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study.

Authors: Rainer Weber; Caroline A Sabin; Nina Friis-Møller; Peter Reiss; Wafaa M El-Sadr; Ole Kirk; Francois Dabis; Matthew G Law; Christian Pradier; Stephane De Wit; Börje Akerlund; Gonzalo Calvo; Antonella d'Arminio Monforte; Martin Rickenbach; Bruno Ledergerber; Andrew N Phillips; Jens D Lundgren
Journal: Arch Intern Med Date: 2006 Aug 14-28

7. Synthesis of the carbocyclic skeleton of abyssomicins C and D.

Authors: Barry B Snider; Yefen Zou
Journal: Org Lett Date: 2005-10-27 Impact factor: 6.005

8. Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis.

Authors: K C Nicolaou; Scott T Harrison; Jason S Chen
Journal: Synthesis (Stuttg) Date: 2009-01-01 Impact factor: 3.157

9. Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: natural thioether Michael addition adducts as antitubercular prodrugs.

Authors: Qian Wang; Fuhang Song; Xue Xiao; Pei Huang; Li Li; Aaron Monte; Wael M Abdel-Mageed; Jian Wang; Hui Guo; Wenni He; Feng Xie; Huanqin Dai; Miaomiao Liu; Caixia Chen; Hao Xu; Mei Liu; Andrew M Piggott; Xueting Liu; Robert J Capon; Lixin Zhang
Journal: Angew Chem Int Ed Engl Date: 2012-12-06 Impact factor: 15.336

10. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

Authors: C Korin Bullen; Gregory M Laird; Christine M Durand; Janet D Siliciano; Robert F Siliciano
Journal: Nat Med Date: 2014-03-23 Impact factor: 53.440

9 in total

1. Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

Authors: Xiachang Wang; Sherif I Elshahawi; Wenlong Cai; Yinan Zhang; Larissa V Ponomareva; Xiabin Chen; Gregory C Copley; James C Hower; Chang-Guo Zhan; Sean Parkin; Jürgen Rohr; Steven G Van Lanen; Khaled A Shaaban; Jon S Thorson
Journal: J Nat Prod Date: 2017-03-30 Impact factor: 4.050

2. Phenogenomic Characterization of a Newly Domesticated and Novel Species from the Genus Verrucosispora.

Authors: Sarah J Kennedy; Celine Grace F Atkinson; Brooke R Tomlinson; Lauren Hammond; Prahathees Eswara; Bill J Baker; Lindsey N Shaw
Journal: Appl Environ Microbiol Date: 2021-09-08 Impact factor: 4.792

3. Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802.

Authors: Jiajia Tu; Siting Li; Jiang Chen; Yongxiang Song; Shaobin Fu; Jianhua Ju; Qinglian Li
Journal: Microb Cell Fact Date: 2018-02-20 Impact factor: 5.328

Review 4. Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis.

Authors: Carmen Sadaka; Edmund Ellsworth; Paul Robert Hansen; Richard Ewin; Peter Damborg; Jeffrey L Watts
Journal: Molecules Date: 2018-06-06 Impact factor: 4.411

Review 5. Marine Pharmacology in 2014-2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors: Alejandro M S Mayer; Aimee J Guerrero; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Fumiaki Nakamura; Nobuhiro Fusetani
Journal: Mar Drugs Date: 2019-12-19 Impact factor: 5.118

9. The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.

Authors: Jonathan A Clinger; Xiachang Wang; Wenlong Cai; Yanyan Zhu; Mitchell D Miller; Chang-Guo Zhan; Steven G Van Lanen; Jon S Thorson; George N Phillips
Journal: Proteins Date: 2020-10-21