Literature DB >> 25559679

Triggering of stroke by ambient temperature variation: a case-crossover study in Maputo, Mozambique.

Joana Gomes1, Albertino Damasceno2, Carla Carrilho3, Vitória Lobo3, Hélder Lopes3, Tavares Madede3, Pius Pravinrai3, Carla Silva-Matos3, Domingos Diogo3, Ana Azevedo4, Nuno Lunet4.   

Abstract

OBJECTIVES: The effect of ambient temperature as a stroke trigger is likely to differ by type of stroke and to depend on non-transient exposures that influence the risk of this outcome. We aimed to quantify the association between ambient temperature variation and stroke, according to clinical characteristics of the events, and other risk factors for stroke.
METHODS: We conducted a case-crossover study based on a 1-year registry of the hospital admissions due to newly occurring ischemic and hemorrhagic stroke events in Maputo, Mozambique's capital city (N=593). The case-period was defined as the 7 days before the stroke event, which was compared to two control periods (14-21 days and 21-28 days before the event). We computed humidity- and precipitation-adjusted odds ratios (OR) and 95% confidence intervals (95%CI) using conditional logistic regression.
RESULTS: An association between minimum temperature declines higher than 2.4 °C in any two consecutive days in the previous week and the occurrence of stroke was observed only for first events (OR=1.43, 95%CI: 1.15-1.76). Stronger and statistically significant associations were observed for hemorrhagic stroke (OR=1.50, 95%CI: 1.07-2.09) and among subjects not exposed to risk factors, including smoking, high serum cholesterol or atrial fibrillation. No differences in the effect of temperature were found according to the patients' vital status 28 days after the event.
CONCLUSIONS: First stroke events, especially of the hemorrhagic type, were triggered by declines in the minimum temperature between consecutive days of the preceding week.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Ambient temperature; Case-crossover; Mozambique; Stroke; Trigger

Mesh:

Year:  2014        PMID: 25559679      PMCID: PMC4339044          DOI: 10.1016/j.clineuro.2014.12.002

Source DB:  PubMed          Journal:  Clin Neurol Neurosurg        ISSN: 0303-8467            Impact factor:   1.876


  33 in total

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