OBJECTIVE: The present study examined the impact of BP from childhood to mid-adulthood on retinal microvascular architecture. METHODS: The Cardiovascular Risk in Young Finns Study included children aged 3-18 years, from five Finnish University cities, with participants chosen randomly from the national population registrar from those areas. The age of participants included in the current analyses in childhood (1980) ranged from three to nine years and in mid-adulthood (2011) ranged from 34 to 40 years (complete data n = 657). Measures of retinal microvasculature architecture measured in adulthood included diameters, tortuosity, lengths, and LDR. RESULTS: Regression analysis showed a strong negative association between childhood systolic BP and adult arteriolar diameter (standardized regression coefficient [β] -0.300; p < 0.001) and with change in systolic BP from childhood to adulthood (β = -0.249; p < 0.001). For arteriolar tortuosity, there was a strong positive association between childhood systolic BP and adult arteriolar tortuosity (β = 0.154; p < 0.001) and no association with change in systolic BP from childhood to adulthood (β = 0.072; p = 0.110). CONCLUSIONS: High BP in childhood and increased BP from childhood to adulthood impacts on retinal microvascular architecture in mid-adulthood.
OBJECTIVE: The present study examined the impact of BP from childhood to mid-adulthood on retinal microvascular architecture. METHODS: The Cardiovascular Risk in Young Finns Study included children aged 3-18 years, from five Finnish University cities, with participants chosen randomly from the national population registrar from those areas. The age of participants included in the current analyses in childhood (1980) ranged from three to nine years and in mid-adulthood (2011) ranged from 34 to 40 years (complete data n = 657). Measures of retinal microvasculature architecture measured in adulthood included diameters, tortuosity, lengths, and LDR. RESULTS: Regression analysis showed a strong negative association between childhood systolic BP and adult arteriolar diameter (standardized regression coefficient [β] -0.300; p < 0.001) and with change in systolic BP from childhood to adulthood (β = -0.249; p < 0.001). For arteriolar tortuosity, there was a strong positive association between childhood systolic BP and adult arteriolar tortuosity (β = 0.154; p < 0.001) and no association with change in systolic BP from childhood to adulthood (β = 0.072; p = 0.110). CONCLUSIONS: High BP in childhood and increased BP from childhood to adulthood impacts on retinal microvascular architecture in mid-adulthood.
Authors: Katherine Y H Chen; David P Burgner; Tien Y Wong; Seang Mei Saw; Swee Chye Quek; Audrey Y C Pang; Seo Wei Leo; Inez B Wong; Diana Zannino; Nigel Curtis; Michael Cheung; Carol Y Cheung; Terence C W Lim Journal: Sci Rep Date: 2017-01-17 Impact factor: 4.379
Authors: Juan C Kupferman; Marc B Lande; Stella Stabouli; Dimitrios I Zafeiriou; Steven G Pavlakis Journal: Pediatr Nephrol Date: 2020-04-29 Impact factor: 3.714
Authors: Matthew D Campbell; Tomi T Laitinen; Alun Hughes; Katja Pahkala; Markus Juonala; Mika Kähönen; Tien Y Wong; Terho Lehtimäki; Nina Hutri-Kähönen; Olli T Raitakari; Robyn J Tapp Journal: J Am Heart Assoc Date: 2018-10-16 Impact factor: 5.501