| Literature DB >> 25556995 |
Raphael Böhm1, Fiona E Fleming2, Andrea Maggioni1, Vi T Dang2, Gavan Holloway2, Barbara S Coulson2, Mark von Itzstein1, Thomas Haselhorst1.
Abstract
Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewis(b) antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific α1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewis(b) and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.Entities:
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Year: 2015 PMID： 25556995 DOI： 10.1038/ncomms6907
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919