| Literature DB >> 25554792 |
Daniel E Neafsey1, Robert M Waterhouse2, Mohammad R Abai3, Sergey S Aganezov4, Max A Alekseyev4, James E Allen5, James Amon6, Bruno Arcà7, Peter Arensburger8, Gleb Artemov9, Lauren A Assour10, Hamidreza Basseri3, Aaron Berlin11, Bruce W Birren11, Stephanie A Blandin12, Andrew I Brockman13, Thomas R Burkot14, Austin Burt15, Clara S Chan16, Cedric Chauve17, Joanna C Chiu18, Mikkel Christensen5, Carlo Costantini19, Victoria L M Davidson20, Elena Deligianni21, Tania Dottorini13, Vicky Dritsou22, Stacey B Gabriel23, Wamdaogo M Guelbeogo24, Andrew B Hall25, Mira V Han26, Thaung Hlaing27, Daniel S T Hughes28, Adam M Jenkins29, Xiaofang Jiang30, Irwin Jungreis16, Evdoxia G Kakani31, Maryam Kamali32, Petri Kemppainen33, Ryan C Kennedy34, Ioannis K Kirmitzoglou35, Lizette L Koekemoer36, Njoroge Laban37, Nicholas Langridge5, Mara K N Lawniczak13, Manolis Lirakis38, Neil F Lobo39, Ernesto Lowy5, Robert M MacCallum13, Chunhong Mao40, Gareth Maslen5, Charles Mbogo41, Jenny McCarthy8, Kristin Michel20, Sara N Mitchell42, Wendy Moore43, Katherine A Murphy18, Anastasia N Naumenko32, Tony Nolan13, Eva M Novoa16, Samantha O'Loughlin15, Chioma Oringanje43, Mohammad A Oshaghi3, Nazzy Pakpour44, Philippos A Papathanos45, Ashley N Peery32, Michael Povelones46, Anil Prakash47, David P Price48, Ashok Rajaraman17, Lisa J Reimer49, David C Rinker50, Antonis Rokas51, Tanya L Russell14, N'Fale Sagnon24, Maria V Sharakhova32, Terrance Shea11, Felipe A Simão52, Frederic Simard19, Michel A Slotman53, Pradya Somboon54, Vladimir Stegniy9, Claudio J Struchiner55, Gregg W C Thomas56, Marta Tojo57, Pantelis Topalis21, José M C Tubio58, Maria F Unger39, John Vontas38, Catherine Walton33, Craig S Wilding59, Judith H Willis60, Yi-Chieh Wu61, Guiyun Yan62, Evgeny M Zdobnov52, Xiaofan Zhou63, Flaminia Catteruccia31, George K Christophides13, Frank H Collins39, Robert S Cornman60, Andrea Crisanti45, Martin J Donnelly64, Scott J Emrich10, Michael C Fontaine65, William Gelbart66, Matthew W Hahn67, Immo A Hansen48, Paul I Howell68, Fotis C Kafatos13, Manolis Kellis16, Daniel Lawson5, Christos Louis69, Shirley Luckhart44, Marc A T Muskavitch70, José M Ribeiro71, Michael A Riehle43, Igor V Sharakhov72, Zhijian Tu73, Laurence J Zwiebel74, Nora J Besansky75.
Abstract
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.Entities:
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Year: 2014 PMID： 25554792 PMCID： PMC4380271 DOI： 10.1126/science.1258522
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728