Evelyn J Corner1, Louise V Hichens2, Kate M Attrill3, Marcela P Vizcaychipi4, Stephen J Brett5, Jonathan M Handy6. 1. Chelsea and Westminster NHS Foundation Trust, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK; Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK. Electronic address: e.corner13@imperial.ac.uk. 2. Chelsea and Westminster NHS Foundation Trust, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK. Electronic address: Louise.Hichens@nbt.nhs.uk. 3. Chelsea and Westminster NHS Foundation Trust, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK. Electronic address: kate.attrill@chelwest.nhs.uk. 4. Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK; Chelsea and Westminster NHS Foundation Trust, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK. Electronic address: m.vizcaychipi@imperial.ac.uk. 5. Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK; Centre for Perioperative Medicine and Critical Care Research, Imperial College NHS Healthcare Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK. Electronic address: stephen.brett@imperial.ac.uk. 6. Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK; Chelsea and Westminster NHS Foundation Trust, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, England, UK. Electronic address: j.m.handy@imperial.ac.uk.
Abstract
INTRODUCTION: Severe burn leads to a state of hypercatabolism, resulting in rapid muscle loss and long-term disability. As survival rates from severe burn are improving, early rehabilitation is essential to facilitate functional recovery. However, there is no way of measuring the degree of disability in the acute stages, and hence, no marker of functional recovery. This hampers both communication and research into interventions to improve functional outcomes. The Chelsea Critical Care Physical Assessment tool (CPAx) is a simple objective measure of function, designed and validated in the general Intensive Care Unit (ICU) cohort. The aim of this study was to test the responsiveness of the CPAx in the burns ICU (BICU) cohort and validate its use. METHODS: Observational study of 52 BICU patients admitted for over 48h. All patients were assessed on the CPAx retrospectively for pre-admission, and prospectively at ICU admission, ICU discharge (or final ICU assessment for non-survivors) and hospital discharge. Analysis of variance, post hoc between group differences in median CPAx score, and floor and ceiling effect (i.e. the percentage of patients scoring full marks (50), or zero) for the four time points were completed. Minimal clinically important difference (MCID) was estimated as half of the standard deviation of the CPAx score at ICU discharge. RESULTS: A total of 30 patients were included in the final analysis; mean age was 47.1 years (SD 21.2), 63.3% were male, with a median burn total body surface area (TBSA) of 30% (IQR 11.3-48.8). There was a significant difference in the analysis of variance in median CPAx scores at all four time points (p<.001). In survivors, the differences in CPAx scores post hoc were significant for all time points (p<.05), aside from ICU discharge and hospital discharge. The CPAx MCID for BICU patients was six. Twenty-three (86.7%) patients scored full marks or zero on the CPAx pre-admission. For survivors, no patients scored full marks or zero on the CPAx at ICU and hospital discharge. On ICU admission 66.7% (n=20) scored zero on the CPAx and no patients scored 50. CONCLUSIONS: The CPAx score appears to be able to detect improvements in physical function as patients recover from acute severe burn. It has a limited floor and ceiling effect in the acute setting and a change in CPAx score of 6 represents clinically important progress. Further work is required in a larger cohort.
INTRODUCTION: Severe burn leads to a state of hypercatabolism, resulting in rapid muscle loss and long-term disability. As survival rates from severe burn are improving, early rehabilitation is essential to facilitate functional recovery. However, there is no way of measuring the degree of disability in the acute stages, and hence, no marker of functional recovery. This hampers both communication and research into interventions to improve functional outcomes. The Chelsea Critical Care Physical Assessment tool (CPAx) is a simple objective measure of function, designed and validated in the general Intensive Care Unit (ICU) cohort. The aim of this study was to test the responsiveness of the CPAx in the burns ICU (BICU) cohort and validate its use. METHODS: Observational study of 52 BICU patients admitted for over 48h. All patients were assessed on the CPAx retrospectively for pre-admission, and prospectively at ICU admission, ICU discharge (or final ICU assessment for non-survivors) and hospital discharge. Analysis of variance, post hoc between group differences in median CPAx score, and floor and ceiling effect (i.e. the percentage of patients scoring full marks (50), or zero) for the four time points were completed. Minimal clinically important difference (MCID) was estimated as half of the standard deviation of the CPAx score at ICU discharge. RESULTS: A total of 30 patients were included in the final analysis; mean age was 47.1 years (SD 21.2), 63.3% were male, with a median burn total body surface area (TBSA) of 30% (IQR 11.3-48.8). There was a significant difference in the analysis of variance in median CPAx scores at all four time points (p<.001). In survivors, the differences in CPAx scores post hoc were significant for all time points (p<.05), aside from ICU discharge and hospital discharge. The CPAx MCID for BICU patients was six. Twenty-three (86.7%) patients scored full marks or zero on the CPAx pre-admission. For survivors, no patients scored full marks or zero on the CPAx at ICU and hospital discharge. On ICU admission 66.7% (n=20) scored zero on the CPAx and no patients scored 50. CONCLUSIONS: The CPAx score appears to be able to detect improvements in physical function as patients recover from acute severe burn. It has a limited floor and ceiling effect in the acute setting and a change in CPAx score of 6 represents clinically important progress. Further work is required in a larger cohort.
Authors: Minxuan Huang; Kitty S Chan; Jennifer M Zanni; Selina M Parry; Saint-Clair G B Neto; Jose A A Neto; Vinicius Z M da Silva; Michelle E Kho; Dale M Needham Journal: Crit Care Med Date: 2016-12 Impact factor: 7.598