Hisanobu Koyama1, Yoshiharu Ohno2, Shinichiro Seki3, Mizuho Nishio2, Takeshi Yoshikawa2, Sumiaki Matsumoto2, Yoshimasa Maniwa4, Tomoo Itoh5, Yoshihiro Nishimura6, Kazuro Sugimura3. 1. Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: hkoyama@med.kobe-u.ac.jp. 2. Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. 3. Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. 4. Department of General Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. 5. Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan. 6. Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Abstract
OBJECTIVES: To determine the appropriate parameters and evaluation method for characterizing solitary pulmonary nodules (SPNs) using quantitative parameters of diffusion-weighted imaging (DWI). METHODS: Thirty-two subjects with 36 SPNs underwent DWI with seven different b values (0, 50, 100, 150, 300, 500, and 1000s/mm(2)). Five quantitative parameters were obtained from the region of interest drawn over each SPN: apparent diffusion coefficients (ADCs), true diffusion coefficients (DCs), and perfusion fractions (PFs), and signal-intensity ratios between lesion and spinal cord from DWI (b values: 1000 [LSR1000] and 500 [LSR500)]). All quantitative parameters and the diagnostic capabilities were statistically compared. RESULTS: SPNs were diagnosed as follow: malignant (n=27) and benign (n=9). Parameter comparisons for malignant and benign showed both LSRs differed significantly (p<0.05). Applying feasible threshold values showed LSR500 specificity (88.9% [8/9]) and accuracy (77.8% [28/36]) were significantly higher than ADC, DC, and PF specificity and accuracy (p<0.05). LSR1000 accuracy (72.2% [26/36]) was significantly higher than DC accuracy, and its specificity (88.9% [8/9]) was significantly higher than ADC, DC, and PF specificities (p<0.05). CONCLUSIONS: For quantitative differentiation of SPNs, LSR evaluation was more useful and practical than ADC, DC, and PF, and choice of b values showed little impact for the differentiation.
OBJECTIVES: To determine the appropriate parameters and evaluation method for characterizing solitary pulmonary nodules (SPNs) using quantitative parameters of diffusion-weighted imaging (DWI). METHODS: Thirty-two subjects with 36 SPNs underwent DWI with seven different b values (0, 50, 100, 150, 300, 500, and 1000s/mm(2)). Five quantitative parameters were obtained from the region of interest drawn over each SPN: apparent diffusion coefficients (ADCs), true diffusion coefficients (DCs), and perfusion fractions (PFs), and signal-intensity ratios between lesion and spinal cord from DWI (b values: 1000 [LSR1000] and 500 [LSR500)]). All quantitative parameters and the diagnostic capabilities were statistically compared. RESULTS: SPNs were diagnosed as follow: malignant (n=27) and benign (n=9). Parameter comparisons for malignant and benign showed both LSRs differed significantly (p<0.05). Applying feasible threshold values showed LSR500 specificity (88.9% [8/9]) and accuracy (77.8% [28/36]) were significantly higher than ADC, DC, and PF specificity and accuracy (p<0.05). LSR1000 accuracy (72.2% [26/36]) was significantly higher than DC accuracy, and its specificity (88.9% [8/9]) was significantly higher than ADC, DC, and PF specificities (p<0.05). CONCLUSIONS: For quantitative differentiation of SPNs, LSR evaluation was more useful and practical than ADC, DC, and PF, and choice of b values showed little impact for the differentiation.
Authors: Natália Henz Concatto; Guilherme Watte; Edson Marchiori; Klaus Irion; José Carlos Felicetti; José Jesus Camargo; Bruno Hochhegger Journal: Eur Radiol Date: 2015-12-05 Impact factor: 5.315
Authors: Natália Henz Concatto; Guilherme Watte; Edson Marchiori; Klaus Irion; José Carlos Felicetti; José Jesus Camargo; Bruno Hochhegger Journal: Eur Radiol Date: 2017-05-05 Impact factor: 5.315
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