Literature DB >> 25552792

Metformin-induced lactic acidosis with emphasis on the anion gap.

Britton Blough1, Amber Moreland1, Adan Mora1.   

Abstract

The presence of an anion gap in a diabetic patient, especially if associated with evidence of compromised renal function, should prompt clinicians to consider metformin as a contributing factor. This consideration is especially important in patients with severe anion gaps associated with lactic acidosis out of proportion to the patient's clinical presentation.

Entities:  

Year:  2015        PMID： 25552792      PMCID： PMC4264704          DOI： 10.1080/08998280.2015.11929178

Source DB:  PubMed          Journal:  Proc (Bayl Univ Med Cent)        ISSN： 0899-8280


  14 in total

1.  Metformin-associated lactic acidosis masquerading as ischemic bowel.

Authors:  Chase S Correia; Kirk A Bronander
Journal:  Am J Med       Date:  2012-02-22       Impact factor: 4.965

2.  Metformin-associated lactic acidosis.

Authors:  B L Pearlman; A Z Fenves; M Emmett
Journal:  Am J Med       Date:  1996-07       Impact factor: 4.965

Review 3.  Metformin.

Authors:  C J Bailey; R C Turner
Journal:  N Engl J Med       Date:  1996-02-29       Impact factor: 91.245

4.  Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.

Authors:  J D Lalau; J M Race
Journal:  Drug Saf       Date:  1999-04       Impact factor: 5.606

5.  Incidence of lactic acidosis in metformin users.

Authors:  M Stang; D K Wysowski; D Butler-Jones
Journal:  Diabetes Care       Date:  1999-06       Impact factor: 19.112

Review 6.  Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

Authors:  Shelley R Salpeter; Elizabeth Greyber; Gary A Pasternak; Edwin E Salpeter Posthumous
Journal:  Cochrane Database Syst Rev       Date:  2010-01-20

7.  Clinical use of the anion gap.

Authors:  M Emmett; R G Narins
Journal:  Medicine (Baltimore)       Date:  1977-01       Impact factor: 1.889

Review 8.  Lactate homeostasis and lactic acidosis.

Authors:  R A Kreisberg
Journal:  Ann Intern Med       Date:  1980-02       Impact factor: 25.391

Review 9.  Biguanide-associated lactic acidosis. Case report and review of the literature.

Authors:  S C Gan; J Barr; A I Arieff; R G Pearl
Journal:  Arch Intern Med       Date:  1992-11

10.  Metformin overdose causes platelet mitochondrial dysfunction in humans.

Authors:  Alessandro Protti; Anna Lecchi; Francesco Fortunato; Andrea Artoni; Noemi Greppi; Sarah Vecchio; Gigliola Fagiolari; Maurizio Moggio; Giacomo Pietro Comi; Giovanni Mistraletti; Barbara Lanticina; Loredana Faraldi; Luciano Gattinoni
Journal:  Crit Care       Date:  2012-10-03       Impact factor: 9.097
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  2 in total

1.  A rare cause of severe lactic acidosis.

Authors:  Saad Saeed; Aditya Kuravi; Matt Rowley; Marwa Saeed
Journal:  BMJ Case Rep       Date:  2015-04-24

2.  Bilateral Ureteral Obstruction Causing Acute Kidney Injury and Resultant Metformin Toxicity.

Authors:  Umar Rashid; Erin M Marra; Vu H Tran
Journal:  Cureus       Date:  2021-11-16
  2 in total

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