Literature DB >> 25552715

Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.

Qi Qiu1, Zhili Xu1, Jie Tian1, Rituparna Moitra1, Sreenivasulu Gunti2, Abner L Notkins2, Andrew P Byrnes3.   

Abstract

Natural IgM inhibits gene transfer by adenovirus type 5 (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transduction in a concentration-dependent manner. We further show that differences in natural IgM between BALB/c and C57BL/6 mice contribute to lower efficiency of Ad5 gene transfer in BALB/c mice.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25552715      PMCID： PMC4337529          DOI： 10.1128/JVI.03217-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

Review 1.  The importance of natural IgM: scavenger, protector and regulator.

Authors:  Michael R Ehrenstein; Clare A Notley
Journal:  Nat Rev Immunol       Date:  2010-10-15       Impact factor: 53.106

Review 2.  Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.

Authors:  Zhao-Hua Zhou; Athanasios G Tzioufas; Abner Louis Notkins
Journal:  J Autoimmun       Date:  2007-09-20       Impact factor: 7.094

3.  The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.

Authors:  Zhao-Hua Zhou; Yahong Zhang; Ya-Fang Hu; Larry M Wahl; John O Cisar; Abner Louis Notkins
Journal:  Cell Host Microbe       Date:  2007-03-15       Impact factor: 21.023

4.  Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver.

Authors:  Frédéric Vigant; Delphyne Descamps; Betsy Jullienne; Stéphanie Esselin; Elisabeth Connault; Paule Opolon; Thierry Tordjmann; Emmanuelle Vigne; Michel Perricaudet; Karim Benihoud
Journal:  Mol Ther       Date:  2008-06-17       Impact factor: 11.454

5.  Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement.

Authors:  Zhili Xu; Qi Qiu; Jie Tian; Jeffrey S Smith; Gina M Conenello; Takashi Morita; Andrew P Byrnes
Journal:  Nat Med       Date:  2013-03-24       Impact factor: 53.440

Review 6.  IgM in microbial infections: taken for granted?

Authors:  Rachael Racine; Gary M Winslow
Journal:  Immunol Lett       Date:  2009-06-17       Impact factor: 3.685

7.  Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo.

Authors:  O Kalyuzhniy; N C Di Paolo; M Silvestry; S E Hofherr; M A Barry; P L Stewart; D M Shayakhmetov
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-07       Impact factor: 11.205

8.  Adenovirus serotype 5 hexon mediates liver gene transfer.

Authors:  Simon N Waddington; John H McVey; David Bhella; Alan L Parker; Kristeen Barker; Hideko Atoda; Rebecca Pink; Suzanne M K Buckley; Jenny A Greig; Laura Denby; Jerome Custers; Takashi Morita; Ivo M B Francischetti; Robson Q Monteiro; Dan H Barouch; Nico van Rooijen; Claudio Napoli; Menzo J E Havenga; Stuart A Nicklin; Andrew H Baker
Journal:  Cell       Date:  2008-02-08       Impact factor: 41.582

Review 9.  The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.

Authors:  Estrella Lopez-Gordo; Laura Denby; Stuart A Nicklin; Andrew H Baker
Journal:  Expert Opin Drug Deliv       Date:  2014-07-18       Impact factor: 6.648

10.  Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus.

Authors:  Carmen Unzu; Ignacio Melero; Aizea Morales-Kastresana; Ana Sampedro; Irantzu Serrano-Mendioroz; Arantza Azpilikueta; María Carmen Ochoa; Juan Dubrot; Eduardo Martínez-Ansó; Antonio Fontanellas
Journal:  PLoS One       Date:  2014-01-21       Impact factor: 3.240
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  15 in total

1.  Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting.

Authors:  Franziska Jönsson; Claudia Hagedorn; Florian Kreppel
Journal:  J Vis Exp       Date:  2018-10-26       Impact factor: 1.355

Review 2.  Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.

Authors:  Franziska Jönsson; Florian Kreppel
Journal:  Virus Genes       Date:  2017-07-28       Impact factor: 2.332

3.  Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates.

Authors:  David Salas; Karin L Kwikkers; Nerea Zabaleta; Andrea Bazo; Harald Petry; Sander J van Deventer; Gloria Gonzalez Aseguinolaza; Valerie Ferreira
Journal:  Blood Adv       Date:  2019-09-10

Review 4.  Retargeting adenoviruses for therapeutic applications and vaccines.

Authors:  Michael A Barry; Jeffrey D Rubin; Shao-Chia Lu
Journal:  FEBS Lett       Date:  2020-02-03       Impact factor: 4.124

5.  Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity.

Authors:  Daniela Anghelina; Eric Lam; Erik Falck-Pedersen
Journal:  J Virol       Date:  2016-06-10       Impact factor: 5.103

6.  Retargeted and detargeted adenovirus for gene delivery to the muscle.

Authors:  Tien V Nguyen; Stephanie S Anguiano-Zarate; William E Matchett; Mary E Barry; Michael A Barry
Journal:  Virology       Date:  2017-11-22       Impact factor: 3.616

Review 7.  Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs.

Authors:  Julio Alonso-Padilla; Tibor Papp; Győző L Kaján; Mária Benkő; Menzo Havenga; Angelique Lemckert; Balázs Harrach; Andrew H Baker
Journal:  Mol Ther       Date:  2015-10-19       Impact factor: 11.454

8.  Firewalls Prevent Systemic Dissemination of Vectors Derived from Human Adenovirus Type 5 and Suppress Production of Transgene-Encoded Antigen in a Murine Model of Oral Vaccination.

Authors:  Julien Revaud; Yves Unterfinger; Nicolas Rol; Muhammad Suleman; Julia Shaw; Sandra Galea; Françoise Gavard; Sandrine A Lacour; Muriel Coulpier; Nicolas Versillé; Menzo Havenga; Bernard Klonjkowski; Gina Zanella; Stéphane Biacchesi; Nathalie Cordonnier; Blaise Corthésy; Juliette Ben Arous; Jennifer P Richardson
Journal:  Front Cell Infect Microbiol       Date:  2018-01-25       Impact factor: 5.293

9.  Comparison of Liver Detargeting Strategies for Systemic Therapy with Oncolytic Adenovirus Serotype 5.

Authors:  Tien V Nguyen; Mary E Barry; Mallory A Turner; Catherine M Crosby; Miguel A Trujillo; John C Morris; Michael A Barry
Journal:  Biomedicines       Date:  2017-08-10

10.  The relevance of coagulation factor X protection of adenoviruses in human sera.

Authors:  M R Duffy; A Doszpoly; G Turner; S A Nicklin; A H Baker
Journal:  Gene Ther       Date:  2016-03-25       Impact factor: 5.250
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