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Literature DB >> 31944286

Retargeting adenoviruses for therapeutic applications and vaccines.

Michael A Barry¹, Jeffrey D Rubin², Shao-Chia Lu².

Abstract

Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off-target cells.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Ad serotypes; detargeting; gain of function; liver; retargeting; sequestration; serotypes

Year: 2020 PMID： 31944286 PMCID： PMC7311308 DOI： 10.1002/1873-3468.13731

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

311 in total

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7 in total

1. A recombinant adenoviral vector with a specific tropism to CD4-positive cells: a new tool for HIV-1 inhibition.

Authors: Abtin Behmardi; Touraj Farazmandfar
Journal: Drug Deliv Transl Res Date: 2022-01-31 Impact factor: 5.671

Review 2. Immunity to enteric viruses.

Authors: Ainsley Lockhart; Daniel Mucida; Roham Parsa
Journal: Immunity Date: 2022-05-10 Impact factor: 43.474

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Journal: Mol Ther Methods Clin Dev Date: 2021-01-20 Impact factor: 6.698

4. Recombinant adenovirus causes prolonged mobilization of macrophages in the anterior chambers of mice.

Authors: Kacie J Meyer; Danielle Pellack; Adam Hedberg-Buenz; Nicholas Pomernackas; Dana Soukup; Kai Wang; John H Fingert; Michael G Anderson
Journal: Mol Vis Date: 2021-12-28 Impact factor: 2.711

5. The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection.

Authors: Manuela Bieri; Rodinde Hendrickx; Michael Bauer; Bin Yu; Tania Jetzer; Birgit Dreier; Peer R E Mittl; Jens Sobek; Andreas Plückthun; Urs F Greber; Silvio Hemmi
Journal: PLoS Pathog Date: 2021-12-15 Impact factor: 6.823

6. Enhanced tumor targeting and timely viral release of mesenchymal stem cells/oncolytic virus complex due to GRP78 and inducible E1B55K expressions greatly increase the antitumor effect of systemic treatment.

Authors: Soojin Choi; Jeong A Hong; Hye Jin Choi; Jae J Song
Journal: Mol Ther Oncolytics Date: 2022-09-17 Impact factor: 6.311

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Authors: Francesca Tasca; Qian Wang; Manuel A F V Gonçalves
Journal: Cells Date: 2020-04-13 Impact factor: 6.600

7 in total