Oliver J Rider1, Andrew J M Lewis2, Adam J Lewandowski2, Ntobeko Ntusi2, Richard Nethononda2, Steffen E Petersen2, Jane M Francis2, Alex Pitcher2, Rajarshi Banerjee2, Paul Leeson2, Stefan Neubauer2. 1. From the Oxford Centre for Clinical Magnetic Resonance Research (O.J.R., A.J.M.L., N.N., R. N., J.M.F., A.P., R.B., S.N.) and Oxford Clinical Cardiovascular Research Facility (A.J.L., P.L.), Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom; and William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom (S.E.P.). oliver.rider@gmail.com. 2. From the Oxford Centre for Clinical Magnetic Resonance Research (O.J.R., A.J.M.L., N.N., R. N., J.M.F., A.P., R.B., S.N.) and Oxford Clinical Cardiovascular Research Facility (A.J.L., P.L.), Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom; and William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom (S.E.P.).
Abstract
BACKGROUND: As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. METHODS AND RESULTS: Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3-59.2 kg/m2) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g per BMI point increase; both P<0.001). Whereas women exhibited RV cavity dilatation (RV end-diastolic volume, +1.0 mL per BMI point increase; P<0.001), BMI was not correlated with RV end-diastolic volume in men (R=0.04; P=0.51). Concentric RV remodeling was present in both sexes, with RV mass/volume ratio being positively correlated to BMI (men, R=0.41; women, R=0.51; both P<0.001). Irrespective of sex, the LV peak filling rate was negatively correlated with both RV mass (men, R=-0.43; women, R=-0.44; both P<0.001) and RV mass/volume ratio (men, R=-0.37; women, R=-0.35; both P<0.001). CONCLUSIONS: A sex difference in RV remodeling exists in obesity. Whereas men exhibit concentric RV remodeling, women exhibit a mixed pattern of eccentric and concentric remodeling. Regardless of sex, reduced LV diastolic function is associated with concentric RV remodeling.
BACKGROUND: As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. METHODS AND RESULTS: Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3-59.2 kg/m2) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g per BMI point increase; both P<0.001). Whereas women exhibited RV cavity dilatation (RV end-diastolic volume, +1.0 mL per BMI point increase; P<0.001), BMI was not correlated with RV end-diastolic volume in men (R=0.04; P=0.51). Concentric RV remodeling was present in both sexes, with RV mass/volume ratio being positively correlated to BMI (men, R=0.41; women, R=0.51; both P<0.001). Irrespective of sex, the LV peak filling rate was negatively correlated with both RV mass (men, R=-0.43; women, R=-0.44; both P<0.001) and RV mass/volume ratio (men, R=-0.37; women, R=-0.35; both P<0.001). CONCLUSIONS: A sex difference in RV remodeling exists in obesity. Whereas men exhibit concentric RV remodeling, women exhibit a mixed pattern of eccentric and concentric remodeling. Regardless of sex, reduced LV diastolic function is associated with concentric RV remodeling.
Authors: Artur Junio Togneri Ferron; Fabiane Valentini Francisqueti; Igor Otávio Minatel; Carol Cristina Vágula de Almeida Silva; Silméia Garcia Zanati Bazan; Koody André Hassemi Kitawara; Jéssica Leite Garcia; Camila Renata Corrêa; Fernando Moreto; Ana Lucia A Ferreira Journal: Nutrients Date: 2018-11-05 Impact factor: 5.717
Authors: Andrew J M Lewis; Ines Abdesselam; Jennifer J Rayner; James Byrne; Barry A Borlaug; Stefan Neubauer; Oliver J Rider Journal: Eur Heart J Cardiovasc Imaging Date: 2022-09-10 Impact factor: 9.130
Authors: Steffen E Petersen; Mihir M Sanghvi; Nay Aung; Jackie A Cooper; José Miguel Paiva; Filip Zemrak; Kenneth Fung; Elena Lukaschuk; Aaron M Lee; Valentina Carapella; Young Jin Kim; Stefan K Piechnik; Stefan Neubauer Journal: PLoS One Date: 2017-10-03 Impact factor: 3.240