Min-Li Zhou1, Kui Zhao2, Shui-Hong Zhou1, Qin-Ying Wang1, Zhou-Jun Zheng3, Zhong-Jie Lu4. 1. Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China. 2. Department of PET/CT Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China. 3. Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China. 4. Department of Radiotherapy, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China.
Abstract
BACKGROUND: Nasal-type natural killer T-cell lymphoma involving the larynx is uncommon. Our search revealed only 12 cases reported previously in the English-language literature. CASE REPORT: We report a case of laryngeal NKTCL. In December 2011, the patient was diagnosed with nasal-type NKTCL and FDG PET/CT showed the lesions were confined to the nasal cavity (stage I). At 1 year after radiotherapy, the patient presented with hoarseness and FDG PET/CT revealed high FDG uptake in the subglottic region and left cervical lymph nodes. A biopsy of the subglottis confirmed NKTCL (stage II). He then received chemotherapy and 14 months after the completion of chemotherapy, FDG PET/CT showed no evidence of recurrence or metastasis. CONCLUSIONS: PET/CT has better sensitivity than other conventional methods and may play an important role in the diagnosis, staging, and follow-up of nasal-type natural killer T-cell lymphoma.
BACKGROUND: Nasal-type natural killer T-cell lymphoma involving the larynx is uncommon. Our search revealed only 12 cases reported previously in the English-language literature. CASE REPORT: We report a case of laryngeal NKTCL. In December 2011, the patient was diagnosed with nasal-type NKTCL and FDG PET/CT showed the lesions were confined to the nasal cavity (stage I). At 1 year after radiotherapy, the patient presented with hoarseness and FDG PET/CT revealed high FDG uptake in the subglottic region and left cervical lymph nodes. A biopsy of the subglottis confirmed NKTCL (stage II). He then received chemotherapy and 14 months after the completion of chemotherapy, FDG PET/CT showed no evidence of recurrence or metastasis. CONCLUSIONS: PET/CT has better sensitivity than other conventional methods and may play an important role in the diagnosis, staging, and follow-up of nasal-type natural killer T-cell lymphoma.
Authors: Dimitrios Karantanis; Rathan M Subramaniam; Patrick J Peller; Val J Lowe; Jolanta M Durski; Douglas A Collins; Evangelos Georgiou; Stephen M Ansell; Gregory A Wiseman Journal: Clin Lymphoma Myeloma Date: 2008-04