Sandra Carvalho1, Paulo S Boggio2, Óscar F Gonçalves3, Ana Rita Vigário4, Marisa Faria4, Soraia Silva4, Gabriel Gaudencio do Rego2, Felipe Fregni5, Jorge Leite6. 1. Neuropsychophysiology Laboratory, CIPsi, School of Psychology (EPsi), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: sandrarc@psi.uminho.pt. 2. Social and Cognitive Neuroscience Laboratory and Developmental Disorders Program, Center for Health and Biological Sciences, Mackenzie Presbyterian University, 01241-001 Sao Paulo, Brazil. 3. Neuropsychophysiology Laboratory, CIPsi, School of Psychology (EPsi), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Counseling and Applied Educational Psychology, Bouvé College of Health Sciences, Northeastern University, Boston, USA. 4. Neuropsychophysiology Laboratory, CIPsi, School of Psychology (EPsi), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. 5. Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 6. Neuropsychophysiology Laboratory, CIPsi, School of Psychology (EPsi), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
BACKGROUND: It has been already shown that delivering tDCS that are spaced by an interval alters its impact on motor plasticity. These effects can be explained, based on metaplasticity in which a previous modification of activity in a neuronal network can change the effects of subsequent interventions in the same network. But to date there is limited data assessing metaplasticity effects in cognitive functioning. OBJECTIVES: The aim of this study was to test several tDCS-based metaplasticity protocols in working memory (WM), by studying the impact of various interstimulation intervals in the performance of a 3-back task. METHODS: Fifteen healthy volunteers per experiment participated in this study. Experiments 1 and 2 tested an anodal tDCS-induced metaplasticity protocol (1 mA, 10 + 10') with 3 interstimulation intervals (10, 30, and 60 min). Experiment 3 determined the effects of a similar protocol-with a 10-min interval between two sessions of cathodal tDCS or anodal plus cathodal tDCS (1 mA, 10 + 10'). RESULTS: Two consecutive sessions of anodal tDCS delivered with a 10 min interval between them did not improve WM performance (P = .095). This effect remained the same if the interval was increased to 30 or 60 min. In contrast, when a 10 min interval was given between two consecutive cathodal tDCS sessions, performance in the 3 back task increased (P = .042). CONCLUSIONS: These results suggest that the polarity effects of tDCS on working memory are dependent on the previous level of activity of the recruited neural population.
BACKGROUND: It has been already shown that delivering tDCS that are spaced by an interval alters its impact on motor plasticity. These effects can be explained, based on metaplasticity in which a previous modification of activity in a neuronal network can change the effects of subsequent interventions in the same network. But to date there is limited data assessing metaplasticity effects in cognitive functioning. OBJECTIVES: The aim of this study was to test several tDCS-based metaplasticity protocols in working memory (WM), by studying the impact of various interstimulation intervals in the performance of a 3-back task. METHODS: Fifteen healthy volunteers per experiment participated in this study. Experiments 1 and 2 tested an anodal tDCS-induced metaplasticity protocol (1 mA, 10 + 10') with 3 interstimulation intervals (10, 30, and 60 min). Experiment 3 determined the effects of a similar protocol-with a 10-min interval between two sessions of cathodal tDCS or anodal plus cathodal tDCS (1 mA, 10 + 10'). RESULTS: Two consecutive sessions of anodal tDCS delivered with a 10 min interval between them did not improve WM performance (P = .095). This effect remained the same if the interval was increased to 30 or 60 min. In contrast, when a 10 min interval was given between two consecutive cathodal tDCS sessions, performance in the 3 back task increased (P = .042). CONCLUSIONS: These results suggest that the polarity effects of tDCS on working memory are dependent on the previous level of activity of the recruited neural population.
Authors: Jorge Leite; Leon Morales-Quezada; Sandra Carvalho; Aurore Thibaut; Deniz Doruk; Chiun-Fan Chen; Steven C Schachter; Alexander Rotenberg; Felipe Fregni Journal: Int J Neural Syst Date: 2017-04-11 Impact factor: 5.866
Authors: A J Woods; A Antal; M Bikson; P S Boggio; A R Brunoni; P Celnik; L G Cohen; F Fregni; C S Herrmann; E S Kappenman; H Knotkova; D Liebetanz; C Miniussi; P C Miranda; W Paulus; A Priori; D Reato; C Stagg; N Wenderoth; M A Nitsche Journal: Clin Neurophysiol Date: 2015-11-22 Impact factor: 3.708
Authors: Jesús Cespón; Claudia Rodella; Paolo M Rossini; Carlo Miniussi; Maria C Pellicciari Journal: Front Aging Neurosci Date: 2017-12-18 Impact factor: 5.750
Authors: Michael A Hunter; Gregory Lieberman; Brian A Coffman; Michael C Trumbo; Mikaela L Armenta; Charles S H Robinson; Matthew A Bezdek; Anthony J O'Sickey; Aaron P Jones; Victoria Romero; Seth Elkin-Frankston; Sean Gaurino; Leonard Eusebi; Eric H Schumacher; Katie Witkiewitz; Vincent P Clark Journal: Heliyon Date: 2018-07-11